Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0226 | 0.1093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0913 | 0.0913 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0226 | 0.1093 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0065 | 0.0125 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0065 | 0.0125 | 0.1028 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0065 | 0.0125 | 0.1145 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1702 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0246 | 0.1218 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0226 | 0.1093 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0065 | 0.0125 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.1702 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1702 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0211 | 0.1003 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0065 | 0.0125 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.1702 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0226 | 0.1093 | 0.1093 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0065 | 0.0125 | 0.1028 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0246 | 0.1218 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0125 | 0.0125 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0065 | 0.0125 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0211 | 0.1003 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.681 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.647 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.301 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.996 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.887 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.835 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.829 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.817 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.