Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0744 | 0.2162 | 0.2162 |
Brugia malayi | Histone deacetylase family protein | 0.2115 | 0.6315 | 0.6315 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.3331 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.3331 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.2115 | 0.6315 | 0.3868 |
Echinococcus multilocularis | histone deacetylase 1 | 0.3331 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.2115 | 0.6315 | 0.3868 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Brugia malayi | histone deacetylase 11 | 0.2092 | 0.6246 | 0.6246 |
Trypanosoma brucei | histone deacetylase 1 | 0.3331 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.2115 | 0.6315 | 0.3868 |
Echinococcus granulosus | histone deacetylase 1 | 0.3331 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.3331 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.2115 | 0.6315 | 0.6315 |
Echinococcus granulosus | histone deacetylase 6 | 0.2115 | 0.6315 | 0.3868 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.2115 | 0.6315 | 0.3868 |
Trypanosoma brucei | histone deacetylase, putative | 0.2115 | 0.6315 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.1348 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.0767 | 0.2231 | 0.2231 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2142 | 0.6395 | 0.4001 |
Giardia lamblia | Histone deacetylase | 0.3331 | 1 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.3331 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.2092 | 0.6246 | 0.3753 |
Schistosoma mansoni | histone deacetylase hda2 | 0.2142 | 0.6395 | 0.4001 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.3331 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.2115 | 0.6315 | 0.0183 |
Echinococcus granulosus | histone deacetylase 6 | 0.2115 | 0.6315 | 0.3868 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2115 | 0.6315 | 0.3868 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.3331 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.2115 | 0.6315 | 0.6315 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2115 | 0.6315 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.2311 | 0.2311 |
Brugia malayi | Histone deacetylase 1 | 0.3331 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.2092 | 0.6246 | 0.6246 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.2115 | 0.6315 | 0.3868 |
Plasmodium vivax | histone deacetylase 1, putative | 0.3331 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.2115 | 0.6315 | 0.6315 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.3331 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3331 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.1348 | 0.3991 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.3331 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.2115 | 0.6315 | 0.3868 |
Schistosoma mansoni | histone deacetylase | 0.3331 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.2115 | 0.6315 | 0.3868 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.3331 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.3331 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.3331 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.3331 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.3331 | 1 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.2115 | 0.6315 | 0.0183 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.2115 | 0.6315 | 0.3868 |
Echinococcus granulosus | histone deacetylase 6 | 0.2142 | 0.6395 | 0.4001 |
Trypanosoma cruzi | histone deacetylase, putative | 0.2115 | 0.6315 | 0.3868 |
Trypanosoma cruzi | histone deacetylase, putative | 0.2115 | 0.6315 | 0.3868 |
Echinococcus multilocularis | histone deacetylase 7 | 0.2115 | 0.6315 | 0.3868 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.3331 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.2115 | 0.6315 | 0.3868 |
Echinococcus multilocularis | histone deacetylase 3 | 0.3331 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3331 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.3331 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.67 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.609 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.588 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.545 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.509 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.489 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.479 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.448 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.