Detailed information for compound 1630287

Basic information

Technical information
  • TDR Targets ID: 1630287
  • Name: NSC643051
  • MW: 278.137 | Formula: C13H9Cl2N3
  • H donors: 1 H acceptors: 1 LogP: 5.08 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)[nH]c1c2nc2n1cccc2.Cl
  • InChi: 1S/C13H8ClN3.ClH/c14-8-4-5-9-10(7-8)15-13-12(9)16-11-3-1-2-6-17(11)13;/h1-7,15H;1H
  • InChiKey: YPQLKUPMSLRIBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-Chloro-5H-pyrido[2',1':2,3]imidazo[4,5-b]indole hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0271 0.3512 0.3327
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) serine/threonine protein kinase 0.0112 0.0277 0.079
Toxoplasma gondii target of rapamycin (TOR), putative 0.0156 0.1179 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0159 0.1242 0.3535
Echinococcus granulosus tyrosine protein kinase ABL1 0.0271 0.3512 0.3327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0156 0.1179 0.0927
Onchocerca volvulus 0.0159 0.1242 0.2981
Loa Loa (eye worm) TK/RYK protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0112 0.0277 0.079
Echinococcus granulosus tyrosine kinase 0.0271 0.3512 0.3327
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) SH2 domain-containing protein 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Echinococcus multilocularis tyrosine kinase 0.0271 0.3512 0.3327
Echinococcus multilocularis SH2 motif 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0159 0.1242 0.0992
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0271 0.3512 0.3327
Brugia malayi SRC-1 0.0271 0.3512 0.3327
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Schistosoma mansoni suppressor of cytokine signaling 0.0159 0.1242 0.0992
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0159 0.1242 0.0992
Brugia malayi RhoGAP domain containing protein 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Schistosoma mansoni tensin 0.0159 0.1242 0.0992
Echinococcus multilocularis tensin 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Echinococcus granulosus tyrosine protein kinase Src42A 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK/Met protein kinase 0.0112 0.0277 0.079
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0112 0.0277 0.2353
Brugia malayi SH2 domain containing protein 0.0271 0.3512 0.3327
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Entamoeba histolytica SH2 domain containing protein 0.0159 0.1242 0.2981
Schistosoma mansoni tyrosine kinase 0.0271 0.3512 0.3327
Loa Loa (eye worm) TK/DDR protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0159 0.1242 0.3535
Brugia malayi Protein kinase domain containing protein 0.0271 0.3512 0.3327
Schistosoma mansoni hypothetical protein 0.0159 0.1242 0.0992
Schistosoma mansoni shc transforming protein 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus multilocularis NCK adaptor protein 0.0159 0.1242 0.0992
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus granulosus expressed conserved protein 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.3061 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0159 0.1242 0.0992
Schistosoma mansoni tyrosine kinase 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0271 0.3512 0.3327
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Brugia malayi hypothetical protein 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Schistosoma mansoni tyrosine kinase 0.0271 0.3512 0.3327
Echinococcus granulosus SH2 domain containing protein 7 0.0159 0.1242 0.0992
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0156 0.1179 0.3238
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0156 0.1179 0.3851
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Onchocerca volvulus 0.0159 0.1242 0.2981
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0159 0.1242 0.3535
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Echinococcus granulosus tyrosine protein kinase shark 0.0271 0.3512 0.3327
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) STAT protein 0.0159 0.1242 0.3535
Schistosoma mansoni hypothetical protein 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0159 0.1242 0.0992
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0112 0.0277 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus multilocularis SH2 motif 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0271 0.3512 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Brugia malayi hypothetical protein 0.0271 0.3512 0.3327
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0156 0.1179 0.2786
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.059 1 1
Onchocerca volvulus 0.0271 0.3512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus granulosus tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0249 0.3061 1
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus SH2 motif 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Trypanosoma brucei protein kinase, putative 0.0112 0.0277 0.0906
Schistosoma mansoni GTPase activating protein 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK protein kinase 0.0271 0.3512 1
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Toxoplasma gondii STE kinase 0.0112 0.0277 0.2353
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0271 0.3512 0.3327
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0159 0.1242 0.0992
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0159 0.1242 0.0992
Brugia malayi protein-tyrosine kinase 0.0271 0.3512 0.3327
Echinococcus multilocularis SHC transforming protein 3 0.0159 0.1242 0.0992
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Onchocerca volvulus 0.0271 0.3512 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Echinococcus granulosus suppressor of cytokine signaling 7 0.0159 0.1242 0.0992
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0156 0.1179 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Echinococcus granulosus tyrosine kinase 0.0271 0.3512 0.3327
Schistosoma mansoni tyrosine kinase 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0156 0.1179 0.3238
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0112 0.0277 0.2353
Loa Loa (eye worm) TK/EPH protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0159 0.1242 0.2981
Loa Loa (eye worm) SH2 domain-containing protein 0.0159 0.1242 0.3535
Schistosoma mansoni tensin 0.0159 0.1242 0.0992
Toxoplasma gondii protein kinase domain-containing protein 0.0112 0.0277 0.2353
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Schistosoma mansoni SH2A 0.0159 0.1242 0.0992
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0271 0.3512 0.3327
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0156 0.1179 0.0927
Brugia malayi Tensin 0.0159 0.1242 0.0992
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0181 0.1678 0.4329
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0156 0.1179 0.0927
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus multilocularis growth factor receptor bound protein 2 0.0159 0.1242 0.0992
Echinococcus granulosus suppressor of cytokine signaling 6 0.0159 0.1242 0.0992
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0156 0.1179 0.3851
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Schistosoma mansoni vav2 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0277 0.079
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Brugia malayi tRNA modification GTPase TrmE family protein 0.0159 0.1242 0.0992
Brugia malayi Variant SH3 domain containing protein 0.0159 0.1242 0.0992
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Loa Loa (eye worm) TK/EGFR protein kinase 0.0112 0.0277 0.079
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0271 0.3512 0.3327
Echinococcus granulosus growth factor receptor bound protein 2 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Echinococcus granulosus c src tyrosine kinase 0.0271 0.3512 0.3327
Echinococcus granulosus N chimaerin 0.0159 0.1242 0.0992
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0159 0.1242 0.0992
Onchocerca volvulus 0.0271 0.3512 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0112 0.0277 0.079
Plasmodium falciparum protein kinase, putative 0.0112 0.0277 0.5
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.059 1 1
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Schistosoma mansoni tensin-related 0.0159 0.1242 0.0992
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0159 0.1242 0.3535
Loa Loa (eye worm) TK/FAK protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0112 0.0277 0.079
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0271 0.3512 0.3327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis tyrosine protein kinase shark 0.0271 0.3512 0.3327
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Plasmodium falciparum protein kinase, putative 0.0112 0.0277 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0112 0.0277 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus SH2 domain containing adapter protein F 0.0159 0.1242 0.0992
Schistosoma mansoni growth factor receptor-bound protein 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Brugia malayi Variant SH3 domain containing protein 0.0159 0.1242 0.0992
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0271 0.3512 0.3327
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0112 0.0277 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus granulosus signal transduction protein lnk realted 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0159 0.1242 0.0992
Echinococcus granulosus tyrosine protein kinase Lyn 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/ROR protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0271 0.3512 0.3327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0277 0.079
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.059 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0159 0.1242 0.2981
Onchocerca volvulus 0.0271 0.3512 1
Trichomonas vaginalis TK family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Onchocerca volvulus 0.0159 0.1242 0.2981
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Echinococcus granulosus SH2 motif 0.0159 0.1242 0.0992
Onchocerca volvulus 0.0271 0.3512 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0159 0.1242 0.0992
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0112 0.0277 0.0906
Echinococcus granulosus tensin 0.0159 0.1242 0.0992
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0159 0.1242 0.0992
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.059 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0159 0.1242 0.3535
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0271 0.3512 0.3327
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis SH2 motif 0.0159 0.1242 0.0992
Echinococcus multilocularis tyrosine protein kinase Abl 0.0271 0.3512 0.3327
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0159 0.1242 0.3535
Echinococcus granulosus tyrosine protein kinase Fyn 0.0271 0.3512 0.3327
Loa Loa (eye worm) phosphatidylinositol 3 0.0249 0.3061 0.8714
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0181 0.1678 0.5481
Schistosoma mansoni tensin 0.0159 0.1242 0.0992
Echinococcus multilocularis tyrosine protein kinase Srms 0.0271 0.3512 0.3327
Plasmodium vivax protein kinase, putative 0.0112 0.0277 0.5
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Echinococcus multilocularis tensin 0.0159 0.1242 0.0992
Loa Loa (eye worm) phosphatidylinositol 3 0.0156 0.1179 0.3356
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Plasmodium falciparum tyrosine kinase-like protein 0.0112 0.0277 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis STE family protein kinase 0.0112 0.0277 0.0906
Brugia malayi Protein kinase domain containing protein 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Onchocerca volvulus 0.0159 0.1242 0.2981
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0277 0.079
Trypanosoma brucei Pseudokinase, putative 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/FER protein kinase 0.0112 0.0277 0.079
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.059 1 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0112 0.0277 0.0906
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0156 0.1179 0.3851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Brugia malayi Protein kinase domain containing protein 0.0271 0.3512 0.3327
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0271 0.3512 0.3327
Schistosoma mansoni tyrosine kinase 0.0271 0.3512 0.3327
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Brugia malayi SH2 domain containing protein 0.0271 0.3512 0.3327
Echinococcus multilocularis 0.0159 0.1242 0.0992
Plasmodium vivax tyrosine kinase-like protein, putative 0.0112 0.0277 0.5
Schistosoma mansoni tensin-related 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK/ACK protein kinase 0.0112 0.0277 0.079
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0112 0.0277 0.079
Brugia malayi Protein kinase domain containing protein 0.0271 0.3512 0.3327
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0112 0.0277 0.5
Brugia malayi cytokine inducible SH2-containing protein 5 0.0159 0.1242 0.0992
Entamoeba histolytica protein kinase, putative 0.0159 0.1242 0.2981
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Brugia malayi Variant SH3 domain containing protein 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus granulosus NCK adaptor protein 0.0159 0.1242 0.0992
Schistosoma mansoni nck2/grb4 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/ABL protein kinase 0.0271 0.3512 1
Schistosoma mansoni adapter molecule crk 0.0159 0.1242 0.0992
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Brugia malayi STAT protein, DNA binding domain containing protein 0.0159 0.1242 0.0992
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0156 0.1179 0.2786
Echinococcus multilocularis signal transduction protein lnk realted 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0156 0.1179 0.0927
Loa Loa (eye worm) TK/CSK protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Loa Loa (eye worm) TK protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) TK/FER protein kinase 0.0271 0.3512 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0271 0.3512 0.3327
Toxoplasma gondii protein kinase 0.0112 0.0277 0.2353
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0159 0.1242 0.0992
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0159 0.1242 0.0992
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0159 0.1242 0.0992
Brugia malayi Tyrosine-protein kinase abl-1 0.0271 0.3512 0.3327
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0156 0.1179 0.0927
Echinococcus granulosus tyrosine protein kinase Src64B 0.0271 0.3512 0.3327
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0277 0.079
Schistosoma mansoni suppressor of cytokine signaling 0.0159 0.1242 0.0992
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0159 0.1242 0.2981
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0112 0.0277 0.079
Brugia malayi Variant SH3 domain containing protein 0.0159 0.1242 0.0992
Echinococcus granulosus tyrosine protein kinase Srms 0.0271 0.3512 0.3327
Loa Loa (eye worm) hypothetical protein 0.0271 0.3512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0112 0.0277 0.0906
Brugia malayi Protein kinase domain containing protein 0.0271 0.3512 0.3327
Trypanosoma cruzi target of rapamycin kinase 3 0.0156 0.1179 0.0927
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0159 0.1242 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Loa Loa (eye worm) hypothetical protein 0.0112 0.0277 0.079
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0159 0.1242 0.0992
Echinococcus multilocularis c src tyrosine kinase 0.0271 0.3512 0.3327
Onchocerca volvulus 0.0159 0.1242 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis N chimaerin 0.0159 0.1242 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Loa Loa (eye worm) hypothetical protein 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Echinococcus multilocularis tyrosine protein kinase Blk 0.0271 0.3512 0.3327
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0249 0.3061 1
Echinococcus granulosus SHC transforming protein 3 0.0159 0.1242 0.0992
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0112 0.0277 0.2353
Schistosoma mansoni tyrosine kinase 0.0271 0.3512 0.3327
Brugia malayi Sex muscle abnormal protein 5 0.0159 0.1242 0.0992
Plasmodium falciparum protein kinase, putative 0.0112 0.0277 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0271 0.3512 0.3327
Brugia malayi SH2 domain containing protein 0.0159 0.1242 0.0992
Loa Loa (eye worm) SRC-1 0.0271 0.3512 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0156 0.1179 0.3851
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0156 0.1179 0.3238
Loa Loa (eye worm) TK/ALK protein kinase 0.0112 0.0277 0.079
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0277 0.0906
Onchocerca volvulus 0.0159 0.1242 0.2981
Trichomonas vaginalis protein kinase atn1, putative 0.0112 0.0277 0.0906
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0159 0.1242 0.3535
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Onchocerca volvulus 0.0271 0.3512 1
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Schistosoma mansoni growth factor receptor-bound protein 0.0159 0.1242 0.0992
Plasmodium falciparum tyrosine kinase-like protein 0.0112 0.0277 0.5
Giardia lamblia GTOR 0.0156 0.1179 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.1179 0.3851
Echinococcus granulosus hypothetical protein 0.0159 0.1242 0.0992
Trichomonas vaginalis protein tyrosine kinase, putative 0.0112 0.0277 0.0906
Leishmania major phosphatidylinositol 3-kinase, putative 0.0156 0.1179 0.3238
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906
Trichomonas vaginalis TKL family protein kinase 0.0112 0.0277 0.0906

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.813 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.799 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.758 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.735 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.665 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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