Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.6 nM | Ability to stimulate uptake of Calcium into Dorsal Root Ganglion(DRG) neurons | ChEMBL. | 8709128 |
EC50 (functional) | = 7.6 nM | Ability to stimulate uptake of Calcium into Dorsal Root Ganglion(DRG) neurons | ChEMBL. | 8709128 |
Ki (binding) | = 0.17 nM | Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]-RTX binding assay. | ChEMBL. | 8709128 |
Ki (binding) | = 0.17 nM | Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]-RTX binding assay. | ChEMBL. | 8709128 |
Relative affinity (binding) | = 0.706 | Binding affinity against Vanilloid receptor in dorsal root ganglion(DRG)membranes relative to resinferatoxin (RTX); not tested | ChEMBL. | 8709128 |
Relative affinity (binding) | = 0.706 | Binding affinity against Vanilloid receptor in dorsal root ganglion(DRG)membranes relative to resinferatoxin (RTX); not tested | ChEMBL. | 8709128 |
Relative Potency (functional) | = 0.21 | Relative potency(RTX) against Dorsal Root Ganglion(DRG)membranes using RTX binding assay. | ChEMBL. | 8709128 |
Relative Potency (functional) | = 0.21 | Relative potency(RTX) against Dorsal Root Ganglion(DRG)membranes using RTX binding assay. | ChEMBL. | 8709128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.