Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0411 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0161 | 0.2145 | 0.2145 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.03 | 0.6503 | 0.647 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.03 | 0.6503 | 0.647 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.2092 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.2092 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.2145 | 0.32 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0209 | 0.3666 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.03 | 0.6503 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0161 | 0.2145 | 0.207 |
Echinococcus granulosus | epidermal growth factor receptor | 0.03 | 0.6503 | 0.647 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0161 | 0.2145 | 0.207 |
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.2145 | 0.32 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0096 | 0.0094 | 0.0094 |
Entamoeba histolytica | protein kinase, putative | 0.0411 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.3706 | 0.5636 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.2092 | 0.3117 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0411 | 1 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0209 | 0.3666 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.03 | 0.6503 | 0.6503 |
Echinococcus multilocularis | insulin receptor | 0.0096 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | IRE protein kinase | 0.0411 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0411 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.042 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.