Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0669 | 0.1793 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0673 | 0.1845 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1313 | 1 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.1313 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.1313 | 1 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0669 | 0.1793 | 0.5 |
Onchocerca volvulus | 0.0529 | 0 | 0.5 | |
Onchocerca volvulus | 0.0529 | 0 | 0.5 | |
Loa Loa (eye worm) | IRE protein kinase | 0.1313 | 1 | 1 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0529 | 0 | 0.5 |
Onchocerca volvulus | 0.0529 | 0 | 0.5 | |
Onchocerca volvulus | 0.0529 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.1313 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.79 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.678 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.67 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.669 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.637 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.