Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.1332 | 0.1332 |
Schistosoma mansoni | protein kinase | 0.0135 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0135 | 1 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0048 | 0.1208 | 0.1208 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0096 | 0.6057 | 0.6057 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0037 | 0 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0135 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0096 | 0.6057 | 0.6057 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0135 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0135 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1208 | 0.1208 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0135 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0096 | 0.6057 | 0.6057 |
Trypanosoma brucei | Casein kinase II | 0.0135 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0096 | 0.6057 | 0.6057 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0096 | 0.6057 | 0.6057 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | IRE protein kinase | 0.0096 | 0.6057 | 0.6057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.752 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.599 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.483 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.417 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.299 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.276 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.