Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0523 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0523 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0523 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0523 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0323 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0259 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0464 | 0.7743 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0523 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0523 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0523 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0523 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0523 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0523 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0523 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0323 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0523 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0523 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0259 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0464 | 0.7743 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0523 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0523 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0523 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0263 | 0.0151 | 0.0151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 15 uM | Cytostatic activity against human MCF7 cells after 72 hrs by MTT assay | ChEMBL. | 22405290 |
IC50 (functional) | = 29 uM | Cytostatic activity against human CEM cells after 3 days by coulter counter analysis | ChEMBL. | 22405290 |
IC50 (functional) | = 31 uM | Cytostatic activity against mouse L1210 cells after 2 days by coulter counter analysis | ChEMBL. | 22405290 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22405290 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.