Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | MAM | 0.0602 | 0.0746 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.0746 | 0.0746 |
Loa Loa (eye worm) | TK protein kinase | 0.2886 | 0.5446 | 0.5448 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0255 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.2814 | 0.5297 | 0.5299 |
Brugia malayi | Protein kinase domain containing protein | 0.2886 | 0.5446 | 0.5446 |
Schistosoma mansoni | hypothetical protein | 0.0602 | 0.0746 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.5098 | 0.9997 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4423 | 0.8609 | 0.8612 |
Onchocerca volvulus | 0.0658 | 0.0862 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase | 0.2886 | 0.5446 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.2886 | 0.5446 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.0746 | 0.0746 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0255 | 0.0033 | 0.0033 |
Echinococcus granulosus | MAM | 0.0602 | 0.0746 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.0746 | 0.0746 |
Brugia malayi | hypothetical protein | 0.0602 | 0.0746 | 0.0746 |
Schistosoma mansoni | hypothetical protein | 0.0602 | 0.0746 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.742 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.693 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.491 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.354 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.285 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.245 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.