Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | histone deacetylase 1 | 0.0423 | 0.655 | 0.3214 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.655 | 0.7152 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0423 | 0.655 | 0.2636 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0522 | 0.9158 | 0.8203 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0423 | 0.655 | 0.3214 |
Brugia malayi | Histone deacetylase family protein | 0.0522 | 0.9158 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0522 | 0.9158 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.0522 | 0.9158 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0522 | 0.9158 | 0.8203 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0522 | 0.9158 | 0.8203 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0423 | 0.655 | 0.2636 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0522 | 0.9158 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0423 | 0.655 | 0.3214 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.5315 | 0.5803 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0423 | 0.655 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0522 | 0.9158 | 0.8203 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0423 | 0.655 | 0.7152 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0522 | 0.9158 | 0.8203 |
Loa Loa (eye worm) | histone deacetylase | 0.0522 | 0.9158 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0553 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0522 | 0.9158 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0423 | 0.655 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0522 | 0.9158 | 0.8203 |
Echinococcus granulosus | histone deacetylase 1 | 0.0423 | 0.655 | 0.2636 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0522 | 0.9158 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0377 | 0.5315 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0522 | 0.9158 | 0.8203 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0423 | 0.655 | 0.3214 |
Trypanosoma brucei | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0423 | 0.655 | 0.2636 |
Trypanosoma brucei | histone deacetylase 4 | 0.0522 | 0.9158 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0423 | 0.655 | 0.3214 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0423 | 0.655 | 0.3214 |
Echinococcus granulosus | histone deacetylase 7 | 0.0522 | 0.9158 | 0.8203 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0423 | 0.655 | 0.3214 |
Plasmodium vivax | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0423 | 0.655 | 0.2636 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0423 | 0.655 | 0.3214 |
Brugia malayi | Histone deacetylase family protein | 0.0522 | 0.9158 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0522 | 0.9158 | 0.8203 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0423 | 0.655 | 0.3214 |
Leishmania major | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0423 | 0.655 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0423 | 0.655 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0522 | 0.9158 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0522 | 0.9158 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0423 | 0.655 | 0.7152 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0423 | 0.655 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0377 | 0.5315 | 0.5803 |
Schistosoma mansoni | histone deacetylase | 0.0423 | 0.655 | 0.2636 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.1 uM | Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 22405922 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22405922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.