Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid sulfatase (microsomal), isozyme S | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_130476 | All targets in OG5_130476 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | arylsulfatase AtsB | steroid sulfatase (microsomal), isozyme S | 583 aa | 470 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0428 | 0.9117 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0428 | 0.9117 | 0.8203 |
Brugia malayi | Histone deacetylase family protein | 0.0428 | 0.9117 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0304 | 0.5085 | 0.5578 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0141 | 0.0155 |
Leishmania major | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0428 | 0.9117 | 0.8203 |
Trypanosoma brucei | histone deacetylase 3 | 0.0428 | 0.9117 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0304 | 0.5085 | 0.5578 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0428 | 0.9117 | 0.8203 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0304 | 0.5085 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0428 | 0.9117 | 0.8203 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0304 | 0.5085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.5085 | 0.5578 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0304 | 0.5085 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0428 | 0.9117 | 0.8203 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0455 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0428 | 0.9117 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0428 | 0.9117 | 0.8203 |
Leishmania major | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0428 | 0.9117 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0428 | 0.9117 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0428 | 0.9117 | 0.8203 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0304 | 0.5085 | 0.5578 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0304 | 0.5085 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0428 | 0.9117 | 0.8203 |
Plasmodium vivax | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0304 | 0.5085 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0428 | 0.9117 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0428 | 0.9117 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0428 | 0.9117 | 0.8203 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.5085 | 0.5578 |
Trypanosoma brucei | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0428 | 0.9117 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0428 | 0.9117 | 1 |
Giardia lamblia | Histone deacetylase | 0.0304 | 0.5085 | 0.5 |
Brugia malayi | hypothetical protein | 0.0347 | 0.6503 | 0.3516 |
Echinococcus granulosus | histone deacetylase 6 | 0.0428 | 0.9117 | 0.8203 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0455 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.44 nM | Inhibition of steroid sulfatase in human MCF7 cells using [3H]E1S as substrate after 20 hrs by scintillation spectrometry | ChEMBL. | 22455789 |
IC50 (binding) | = 3.4 nM | Inhibition of steroid sulfatase in human placental microsomes using [3H]E1S as substrate after 30 mins by scintillation spectrometry | ChEMBL. | 22455789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.