Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Histone deacetylase | 0.0201 | 0.6267 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0201 | 0.6267 | 0.6717 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0262 | 0.9329 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0262 | 0.9329 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0201 | 0.6267 | 0.6717 |
Echinococcus granulosus | histone deacetylase 7 | 0.0262 | 0.9329 | 0.8203 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0276 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.6267 | 0.6717 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0262 | 0.9329 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0262 | 0.9329 | 0.8203 |
Plasmodium falciparum | histone deacetylase 2 | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0201 | 0.6267 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.0262 | 0.9329 | 0.8203 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0262 | 0.9329 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0201 | 0.6267 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0262 | 0.9329 | 0.8203 |
Entamoeba histolytica | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0201 | 0.6267 | 0.6717 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0201 | 0.6267 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0262 | 0.9329 | 0.8203 |
Leishmania major | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0276 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0262 | 0.9329 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Brugia malayi | Histone deacetylase family protein | 0.0262 | 0.9329 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.6267 | 0.6717 |
Echinococcus granulosus | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0201 | 0.6267 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 60 uM | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 22406153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.