Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase 7A | 0.0262 | 0.9329 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Plasmodium vivax | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0201 | 0.6267 | 0.6717 |
Giardia lamblia | Histone deacetylase | 0.0201 | 0.6267 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0276 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0262 | 0.9329 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.6267 | 0.6717 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Leishmania major | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0262 | 0.9329 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0201 | 0.6267 | 0.6717 |
Trypanosoma brucei | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0262 | 0.9329 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0262 | 0.9329 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0201 | 0.6267 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0262 | 0.9329 | 0.8203 |
Echinococcus multilocularis | histone deacetylase | 0.0262 | 0.9329 | 0.8203 |
Echinococcus granulosus | histone deacetylase | 0.0262 | 0.9329 | 0.8203 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0201 | 0.6267 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0262 | 0.9329 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0262 | 0.9329 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0262 | 0.9329 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0262 | 0.9329 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0276 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0262 | 0.9329 | 0.8203 |
Leishmania major | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0201 | 0.6267 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0262 | 0.9329 | 0.8203 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.6267 | 0.6717 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0262 | 0.9329 | 0.8203 |
Plasmodium falciparum | histone deacetylase, putative | 0.0262 | 0.9329 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0201 | 0.6267 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0201 | 0.6267 | 0.6717 |
Entamoeba histolytica | histone deacetylase, putative | 0.0201 | 0.6267 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 60 uM | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 22406153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.