Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1307 | 1 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.1307 | 1 | 0.5 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.1178 | 0.8993 | 0.8989 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1307 | 1 | 0.5 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.1178 | 0.8993 | 0.8993 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0091 | 0.052 | 0.0486 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.1307 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.1307 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1307 | 1 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.1307 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0091 | 0.052 | 0.052 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1307 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1307 | 1 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0029 | 0.0036 | 0.0036 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.1307 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0036 | 0.0036 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0029 | 0.0036 | 0.0036 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1307 | 1 | 0.5 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0129 | 0.0818 | 0.0818 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.1307 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0091 | 0.052 | 0.052 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1307 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0036 | 0.0036 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.1307 | 1 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0029 | 0.0036 | 0.0036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.