Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid sulfatase (microsomal), isozyme S | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_130476 | All targets in OG5_130476 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | arylsulfatase AtsB | steroid sulfatase (microsomal), isozyme S | 583 aa | 470 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.3075 | 0.912 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.3329 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.1064 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0693 | 0.088 | 0.088 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.1318 | 0.3042 | 0.3881 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0439 | 0 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.2704 | 0.7838 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.2265 | 0.6319 | 0.6319 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0439 | 0 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0693 | 0.088 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0693 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1318 | 0.3042 | 0.3335 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.2265 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0693 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.2265 | 0.6319 | 0.6929 |
Loa Loa (eye worm) | hypothetical protein | 0.3329 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.245 | 0.6958 | 0.8878 |
Loa Loa (eye worm) | glutamate receptor | 0.2704 | 0.7838 | 0.7838 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of steroid sulfatase in human MCF7 cells using [3H]E1S as substrate after 20 hrs by scintillation spectrometry | ChEMBL. | 22455789 | |
IC50 (binding) | > 10000 nM | Inhibition of steroid sulfatase in human placental microsomes using [3H]E1S as substrate after 30 mins by scintillation spectrometry | ChEMBL. | 22455789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.