Detailed information for compound 1636418

Basic information

Technical information
  • TDR Targets ID: 1636418
  • Name: imidazo[1,2-a]pyridin-2-ylmethylsulfanylmetha nimidamide hydrochloride
  • MW: 242.728 | Formula: C9H11ClN4S
  • H donors: 1 H acceptors: 1 LogP: 2.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)SCc1nc2n(c1)cccc2.Cl
  • InChi: 1S/C9H10N4S.ClH/c10-9(11)14-6-7-5-13-4-2-1-3-8(13)12-7;/h1-5H,6H2,(H3,10,11);1H
  • InChiKey: VUXARIKFPIFJIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • imidazo[1,2-a]pyridin-2-ylmethylsulfanylformamidine hydrochloride
  • (2-imidazo[1,2-a]pyridinylmethylthio)formamidine hydrochloride
  • (imidazo[1,2-a]pyridin-2-ylmethylthio)formamidine hydrochloride
  • NSC652563

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0186 1 1
Brugia malayi Dopamine receptor 0.0025 0 0.5
Brugia malayi Serotonin receptor 0.0025 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0186 1 1
Brugia malayi Dopamine receptor protein 1 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0025 0 0.5
Brugia malayi AKH receptor 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Brugia malayi GnHR receptor homolog 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Echinococcus multilocularis serotonin receptor 0.0186 1 1
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi sulfakinin receptor protein 0.0025 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0 0.5
Brugia malayi neuropeptide F receptor 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Toxoplasma gondii PAN domain-containing protein 0.0167 0.8781 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi Serotonin receptor 0.0025 0 0.5
Echinococcus multilocularis serotonin receptor 0.0186 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0 0.5
Brugia malayi neuropeptide F receptor 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi G protein-coupled receptor 0.0025 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0 0.5
Brugia malayi larval opioid receptor 0.0025 0 0.5
Toxoplasma gondii PAN domain-containing protein 0.0167 0.8781 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi G-protein coupled receptor 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Brugia malayi G-protein coupled receptor 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0186 1 1
Onchocerca volvulus 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Brugia malayi putative neuropeptide receptor 0.0025 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi hypothetical protein 0.0025 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0 0.5
Onchocerca volvulus 0.0025 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0 0.5
Brugia malayi RE15519p 0.0025 0 0.5

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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