Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.1796 | 0.4276 | 0.4276 |
Schistosoma mansoni | tyrosine kinase | 0.3948 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1764 | 0.4191 | 0.4191 |
Echinococcus granulosus | insulin receptor | 0.3948 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1764 | 0.4191 | 0.4191 |
Toxoplasma gondii | MAPEG family protein | 0.3656 | 0.9222 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2152 | 0.5223 | 0.1655 |
Echinococcus multilocularis | 0.0516 | 0.0871 | 0.0871 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.1796 | 0.4276 | 0.4276 |
Echinococcus multilocularis | insulin receptor | 0.3948 | 1 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.3656 | 0.9222 | 0.9222 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.3948 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1764 | 0.4191 | 0.4191 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1796 | 0.4276 | 0.4276 |
Schistosoma mansoni | tyrosine kinase | 0.1796 | 0.4276 | 0.4276 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.3656 | 0.9222 | 0.9222 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1796 | 0.4276 | 0.4276 |
Schistosoma mansoni | tyrosine kinase | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.3948 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.3948 | 1 | 1 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.3656 | 0.9222 | 0.9222 |
Brugia malayi | Protein kinase domain containing protein | 0.2184 | 0.5308 | 0.1803 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.3656 | 0.9222 | 0.9222 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1796 | 0.4276 | 0.4276 |
Schistosoma mansoni | tyrosine kinase | 0.1796 | 0.4276 | 0.4276 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1796 | 0.4276 | 0.4276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.