Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.009 | 0.009 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.1804 | 0.8984 | 0.8984 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.1804 | 0.8984 | 0.8984 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.2002 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.2002 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2002 | 1 | 0.5 |
Echinococcus granulosus | lysosomal protective protein | 0.2002 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.2002 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.009 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.2002 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.2002 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.009 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.009 | 0.009 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.009 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.2002 | 1 | 1 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.2002 | 1 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.2002 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.009 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.009 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2002 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.009 | 0.009 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2002 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.2002 | 1 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.009 | 0.5 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.2002 | 1 | 1 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0198 | 0.0741 | 0.0741 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.88 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.741 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.723 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.719 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.717 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.649 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.63 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.537 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.472 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.466 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.