Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0023 | 0.0023 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0208 | 0.0664 | 0.0664 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0465 | 0.0465 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2715 | 1 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0023 | 0.0023 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0268 | 0.0888 | 0.0888 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0173 | 0.0534 | 0.0534 |
Echinococcus multilocularis | lysosomal protective protein | 0.2715 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.0253 | 0.0253 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.083 | 0.2981 | 0.2981 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.2715 | 1 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0173 | 0.0534 | 0.0534 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.2715 | 1 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.0178 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0118 | 0.0118 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.2715 | 1 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.2715 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.2715 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2715 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2715 | 1 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0 | 0.5 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.2447 | 0.9001 | 0.9001 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.2715 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0155 | 0.0465 | 0.0465 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0023 | 0.0023 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.2447 | 0.9001 | 0.9001 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0079 | 0.0079 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.2715 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0023 | 0.0023 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0664 | 0.0664 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0079 | 0.0079 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.2715 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0535 | 0.0535 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.0253 | 0.0253 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.2715 | 1 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0023 | 0.0023 |
Onchocerca volvulus | 0.0155 | 0.0465 | 0.0465 | |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0535 | 0.0535 |
Echinococcus multilocularis | geminin | 0.0174 | 0.0535 | 0.0535 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0023 | 0.0023 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0044 | 0.0044 |
Echinococcus granulosus | lysosomal protective protein | 0.2715 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0079 | 0.0079 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0174 | 0.0535 | 0.0535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 25 uM | Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay | ChEMBL. | 21812421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.