Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.2397 | 0.654 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.6847 | 0.8837 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.059 | 0.2038 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.3111 | 0.8597 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0.0128 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.7731 | 1 |
Brugia malayi | Sodium/calcium exchanger protein | 0.003 | 0.0794 | 0.2552 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.014 | 0.7731 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.2397 | 0.2985 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.6847 | 0.8837 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.059 | 0.2038 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.3111 | 0.8597 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0128 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.2397 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.059 | 0.2038 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0074 | 0.3598 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0128 | 0.0411 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0128 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0128 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0128 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0.0128 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3111 | 0.3022 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.2397 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.059 | 0.1898 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.2397 | 0.7706 |
Brugia malayi | glutathione reductase | 0.0055 | 0.2397 | 0.7706 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.059 | 0.2038 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0128 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.2397 | 0.6009 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0074 | 0.3598 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.3111 | 0.8381 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.6847 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3111 | 0.3022 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.059 | 0.2038 |
Brugia malayi | RNA binding protein | 0.0066 | 0.3111 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.3111 | 1 |
Leishmania major | trypanothione reductase | 0.0055 | 0.2397 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0.0128 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.2397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0794 | 0.0677 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.014 | 0.7731 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.2397 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.2397 | 0.654 |
Echinococcus granulosus | sodium calcium exchanger | 0.0074 | 0.3598 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.6847 | 0.8837 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.3111 | 0.8381 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0128 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.2397 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.2397 | 0.6009 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0074 | 0.3598 | 0.3515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3111 | 0.3022 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.3111 | 0.8381 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0128 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.3111 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3111 | 0.3022 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.2397 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.059 | 0.2038 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.6847 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3111 | 0.3022 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.6847 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.014 | 0.7731 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.059 | 0.2038 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.2397 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.059 | 0.2038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.763 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.589 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.515 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.25 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.224 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.171 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.136 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.