Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0224 | 0.0914 | 0.3206 |
Brugia malayi | Fibulin-1 precursor | 0.0245 | 0.1097 | 0.395 |
Onchocerca volvulus | 0.0224 | 0.0914 | 0.3206 | |
Leishmania major | hypothetical protein, conserved | 0.042 | 0.2589 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.0914 | 0.089 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0245 | 0.1097 | 0.1096 |
Echinococcus granulosus | Mastin | 0.0702 | 0.4995 | 0.5484 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.0914 | 0.3529 |
Echinococcus granulosus | Tolloid protein 1 | 0.0245 | 0.1097 | 0.1096 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.0914 | 0.3529 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0702 | 0.4995 | 0.5484 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0245 | 0.1097 | 0.4238 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1097 | 0.4238 |
Echinococcus multilocularis | fibrillin 1 | 0.0245 | 0.1097 | 0.1096 |
Echinococcus granulosus | chromobox protein 2 | 0.1171 | 0.9007 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.042 | 0.2589 | 0.1676 |
Echinococcus granulosus | tissue type plasminogen activator | 0.042 | 0.2589 | 0.2776 |
Schistosoma mansoni | chromobox protein | 0.1171 | 0.9007 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.042 | 0.2589 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0702 | 0.4995 | 0.5484 |
Echinococcus multilocularis | chromobox protein 2 | 0.1171 | 0.9007 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.042 | 0.2589 | 0.2776 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0123 | 0.0476 |
Schistosoma mansoni | egf-like domain protein | 0.0245 | 0.1097 | 0.1096 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0245 | 0.1097 | 0.1096 |
Echinococcus granulosus | laminin | 0.0245 | 0.1097 | 0.1096 |
Echinococcus multilocularis | Mastin | 0.0702 | 0.4995 | 0.5484 |
Brugia malayi | Kringle domain containing protein | 0.042 | 0.2589 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.0914 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0123 | 0.0476 |
Echinococcus multilocularis | laminin | 0.0245 | 0.1097 | 0.1096 |
Loa Loa (eye worm) | trypsin family protein | 0.0131 | 0.0123 | 0.0476 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.042 | 0.2589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.2589 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.023 | 0.0963 | 0.372 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.042 | 0.2589 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0123 | 0.0476 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0245 | 0.1097 | 0.4238 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0123 | 0.0476 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0702 | 0.4995 | 0.5484 |
Schistosoma mansoni | integrin alpha | 0.0149 | 0.0274 | 0.0169 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.042 | 0.2589 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.042 | 0.2589 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0245 | 0.1097 | 0.395 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1097 | 0.4238 |
Mycobacterium ulcerans | hypothetical protein | 0.0131 | 0.0123 | 0.5 |
Onchocerca volvulus | 0.042 | 0.2589 | 1 | |
Toxoplasma gondii | PAN domain-containing protein | 0.1287 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0702 | 0.4995 | 0.5484 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0123 | 0.0476 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0245 | 0.1097 | 0.395 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0245 | 0.1097 | 0.395 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0149 | 0.0274 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1097 | 0.4238 |
Echinococcus multilocularis | enteropeptidase | 0.0702 | 0.4995 | 0.5484 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0245 | 0.1097 | 0.4238 |
Schistosoma mansoni | hypothetical protein | 0.042 | 0.2589 | 0.2776 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1097 | 0.4238 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1097 | 0.4238 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibitory activity (binding) | = 683 nM | Inhibitory activity against serine protease chymase was determined | ChEMBL. | 12467610 |
Inhibitory activity (binding) | = 683 nM | Inhibitory activity against serine protease chymase was determined | ChEMBL. | 12467610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.