Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1131 | 0.4754 | 0.8006 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1119 | 0.4647 | 0.7822 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1268 | 0.5912 | 0.5867 |
Trichomonas vaginalis | AGC family protein kinase | 0.0583 | 0.0107 | 0.0107 |
Trichomonas vaginalis | AGC family protein kinase | 0.0631 | 0.0514 | 0.0514 |
Echinococcus granulosus | nervana 2 | 0.1119 | 0.4647 | 0.7822 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.175 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0583 | 0.0107 | 0.0107 |
Trypanosoma cruzi | Protein kinase B | 0.1179 | 0.5161 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1179 | 0.5161 | 0.5109 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1702 | 0.9593 | 0.9589 |
Entamoeba histolytica | protein kinase, putative | 0.175 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1119 | 0.4647 | 0.7822 |
Entamoeba histolytica | protein kinase, putative | 0.175 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1179 | 0.5161 | 0.5109 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1131 | 0.4754 | 0.8006 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1179 | 0.5161 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1179 | 0.5161 | 0.8707 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1119 | 0.4647 | 0.7822 |
Trichomonas vaginalis | AGC family protein kinase | 0.0583 | 0.0107 | 0.0107 |
Entamoeba histolytica | protein kinase 2, putative | 0.1131 | 0.4754 | 0.4697 |
Echinococcus granulosus | sphingosine kinase 1 | 0.1268 | 0.5912 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1131 | 0.4754 | 0.8006 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1179 | 0.5161 | 0.8707 |
Entamoeba histolytica | protein kinase, putative | 0.1702 | 0.9593 | 0.9589 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.175 | 1 | 0.5 |
Schistosoma mansoni | sphingosine kinase A B | 0.1268 | 0.5912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1268 | 0.5912 | 0.5867 |
Mycobacterium ulcerans | hypothetical protein | 0.1268 | 0.5912 | 0.5 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1702 | 0.9593 | 0.9589 |
Echinococcus granulosus | nervana 2 | 0.1119 | 0.4647 | 0.7822 |
Toxoplasma gondii | AGC kinase | 0.1702 | 0.9593 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.1119 | 0.4647 | 0.7822 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1179 | 0.5161 | 0.8707 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1131 | 0.4754 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.1268 | 0.5912 | 0.5 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1131 | 0.4754 | 0.5 |
Giardia lamblia | Kinase, AGC PKA | 0.1131 | 0.4754 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.1119 | 0.4647 | 0.7822 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1119 | 0.4647 | 0.7822 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.1268 | 0.5912 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.175 | 1 | 1 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.1268 | 0.5912 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1179 | 0.5161 | 0.8707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.903 | Inhibition of human neuraminidase2 using 4-MU-NANA as substrate assessed as residual activity at 100 uM preincubated for 15 mins prior addition of substrate measured after 5 mins by fluorimetry relative to control in presence of 125 uM EDTA | ChEMBL. | 22410247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.