Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0319 | 0.1337 | 0.1337 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0202 | 0.0501 | 1 |
Entamoeba histolytica | Rho family GTPase | 0.0132 | 0 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0202 | 0.0501 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0202 | 0.0501 | 0.0501 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.1043 | 0.6504 | 0.6504 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1043 | 0.6504 | 0.7097 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.1337 | 0.1337 |
Loa Loa (eye worm) | glutamate receptor | 0.1245 | 0.7946 | 0.7946 |
Trichomonas vaginalis | rho3, putative | 0.0132 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1533 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0202 | 0.0501 | 0.0631 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1416 | 0.9164 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1533 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.049 | 0.2555 | 0.2555 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.1128 | 0.7111 | 0.8948 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0607 | 0.3391 | 0.4267 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0501 | 0.0501 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1245 | 0.7946 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.0501 | 0.0547 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0319 | 0.1337 | 0.1683 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0319 | 0.1337 | 0.1337 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0202 | 0.0501 | 0.0501 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.1043 | 0.6504 | 0.6504 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0607 | 0.3391 | 0.37 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.