Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1005 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.1005 | 1 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1005 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.1005 | 1 | 0.5 |
Onchocerca volvulus | 0.1005 | 1 | 0.5 | |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1005 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1005 | 1 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1005 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1005 | 1 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1005 | 1 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1005 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1005 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1005 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1005 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1005 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1005 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.1005 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1005 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1005 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1005 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1005 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1005 | 1 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.1005 | 1 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1005 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 81 % | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells at 1 uM after 2 hrs by liquid scintillation counting | ChEMBL. | 22464684 |
Activity (binding) | = 99 % | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells at 1 uM after 2 hrs by liquid scintillation counting | ChEMBL. | 22464684 |
EC50 (functional) | = 12.2 nM | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as calcium mobilization after 1 hrs by fluorescence analysis | ChEMBL. | 22464684 |
EC50 (functional) | = 140 nM | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as [35S]GTP-gamma-S binding after 3 hrs by liquid scintillation counting | ChEMBL. | 22464684 |
Emax (functional) | = 97 % | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as calcium mobilization after 1 hrs by fluorescence analysis relative to U69593 | ChEMBL. | 22464684 |
Emax (functional) | = 104 % | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as [35S]GTP-gamma-S binding after 3 hrs by liquid scintillation counting relative to (-)U50488 | ChEMBL. | 22464684 |
Ki (binding) | = 30 nM | Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | ChEMBL. | 22464684 |
Ki (binding) | > 1000 nM | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | ChEMBL. | 22464684 |
Ki (binding) | > 10000 nM | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | ChEMBL. | 22464684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.