Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0685 | 0.9727 | 1 | |
Onchocerca volvulus | 0.0612 | 0.8614 | 0.8835 | |
Brugia malayi | hypothetical protein | 0.0312 | 0.4032 | 0.4037 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0685 | 0.9727 | 0.9716 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.1304 | 0.0973 |
Onchocerca volvulus | 0.0312 | 0.4032 | 0.4037 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0134 | 0.1304 | 1 |
Onchocerca volvulus | 0.0073 | 0.0366 | 0.0199 | |
Onchocerca volvulus | 0.0073 | 0.0366 | 0.0199 | |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1304 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0685 | 0.9727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0366 | 0.0377 |
Brugia malayi | Kringle domain containing protein | 0.0134 | 0.1304 | 0.1181 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0073 | 0.0366 | 0.0199 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0082 | 0.0505 | 0.0144 |
Onchocerca volvulus | 0.0134 | 0.1304 | 0.1181 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0366 | 0.0377 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0073 | 0.0366 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0685 | 0.9727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0176 | 0.0181 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.0366 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0134 | 0.1304 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.1304 | 0.1181 |
Brugia malayi | Trypsin family protein | 0.0073 | 0.0366 | 0.0199 |
Brugia malayi | Trypsin family protein | 0.0685 | 0.9727 | 1 |
Onchocerca volvulus | 0.0073 | 0.0366 | 0.0199 | |
Brugia malayi | hypothetical protein | 0.0073 | 0.0366 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0366 | 0.0377 |
Leishmania major | hypothetical protein, conserved | 0.0134 | 0.1304 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0073 | 0.0366 | 0.0199 |
Onchocerca volvulus | 0.0073 | 0.0366 | 0.0199 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0134 | 0.1304 | 0.134 |
Toxoplasma gondii | kringle domain-containing protein | 0.0134 | 0.1304 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0073 | 0.0366 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.4032 | 0.4145 |
Loa Loa (eye worm) | trypsin family protein | 0.0073 | 0.0366 | 0.0377 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0134 | 0.1304 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0134 | 0.1304 | 0.5 |
Onchocerca volvulus | 0.0073 | 0.0366 | 0.0199 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0134 | 0.1304 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0366 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0366 | 0.0377 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1500 nM | Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluorescence polarization assay | ChEMBL. | 24900346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.