Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycine receptor subunit beta | 0.0056 | 0.1578 | 0.1578 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0217 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0227 | 0.0227 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.1003 | 0.1003 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0056 | 0.1578 | 0.1578 |
Onchocerca volvulus | Putative nachr subunit | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.0805 | 0.0805 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0056 | 0.1578 | 0.1578 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0217 | 1 | 0.5 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.003 | 0.0227 | 0.0227 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0056 | 0.1578 | 0.1578 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0217 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | GABA receptor subunit | 0.003 | 0.0227 | 0.0227 |
Echinococcus granulosus | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Onchocerca volvulus | 0.0056 | 0.1578 | 0.1578 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.003 | 0.0227 | 0.0227 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | nAChR subunit | 0.003 | 0.0227 | 0.0227 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.003 | 0.0227 | 0.0227 |
Onchocerca volvulus | 0.0056 | 0.1578 | 0.1578 | |
Onchocerca volvulus | 0.0056 | 0.1578 | 0.1578 | |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0.0227 | 0.0227 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0217 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Onchocerca volvulus | 0.0056 | 0.1578 | 0.1578 | |
Brugia malayi | Cation transporter family protein | 0.0056 | 0.1578 | 0.1578 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0217 | 1 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0217 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Onchocerca volvulus | 0.0056 | 0.1578 | 0.1578 | |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.003 | 0.0227 | 0.0227 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0217 | 1 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | nAChR subunit | 0.003 | 0.0227 | 0.0227 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0217 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0217 | 1 | 0.5 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0056 | 0.1578 | 0.1578 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0217 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.003 | 0.0227 | 0.0227 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Onchocerca volvulus | 0.003 | 0.0227 | 0.0227 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | LGC-31 protein | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0805 | 0.0805 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | ACC-1 protein | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Cation transporter family protein | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0056 | 0.1578 | 0.1578 |
Onchocerca volvulus | 0.0056 | 0.1578 | 0.1578 | |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | Cation transporter family protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0056 | 0.1578 | 0.1578 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0217 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0217 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0217 | 1 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0056 | 0.1578 | 0.1578 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0217 | 1 | 0.5 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.003 | 0.0227 | 0.0227 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.1003 | 0.1003 |
Schistosoma mansoni | nAChR subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0217 | 1 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.052 | 0.052 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0056 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0056 | 0.1578 | 0.1578 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0217 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0056 | 0.1578 | 0.1578 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0217 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1578 | 0.1578 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0217 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.021 ug ml-1 | Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis | ChEMBL. | 22324723 |
GI50 (functional) | = 0.37 ug ml-1 | Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22324723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.