Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0077 | 1 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0077 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0077 | 1 | 0.5 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0077 | 1 | 1 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0077 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0077 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0056 | 0.6603 | 1 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0024 | 0.1587 | 0.5 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0024 | 0.1587 | 0.5 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0024 | 0.1587 | 0.5 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0024 | 0.1587 | 0.5 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0024 | 0.1587 | 0.5 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0024 | 0.1587 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.