Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microsomal glutathione s-transferase | 0.6856 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0375 | 0.0085 | 0.1827 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0625 | 0.0467 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.6856 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0375 | 0.0085 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0625 | 0.0467 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.6856 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0625 | 0.0467 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0625 | 0.0467 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.6856 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0625 | 0.0467 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 58 % | Inhibition of Mycobacterium tuberculosis recombinant InhA expressed in Escherichia coli using trans-2-dodecenoyl-coenzyme-A as substrate at 50 uM | ChEMBL. | 22483635 |
MIC (functional) | = 2 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by two-fold serial dilution method | ChEMBL. | 22483635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.