TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 526.598 | Formula: C28H30O8S
H donors: 0 H acceptors: 5 LogP: 4.38 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)C(=O)c1csc2c1cccc2
InChi: 1S/C28H30O8S/c1-14(29)35-19-11-18(25(32)34-4)27(2)10-9-17-26(33)36-20(12-28(17,3)24(27)23(19)31)22(30)16-13-37-21-8-6-5-7-15(16)21/h5-8,13,17-20,24H,9-12H2,1-4H3/t17-,18-,19-,20-,24-,27-,28-/m0/s1
InChiKey: JGWKXFYZDYSKQR-GACSAELKSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	opioid receptor, mu 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, kappa 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0012	0.0021	0.5
Brugia malayi	Serotonin receptor	0.0012	0.0021	0.0509
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Schistosoma mansoni	hypothetical protein	0.0012	0.0021	0.045
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.0021	0.045
Schistosoma mansoni	histamine h1 receptor	0.0012	0.0021	0.045
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0021	0.0054
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0021	0.045
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0021	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0459	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0021	0.0054
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0021	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.0021	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0331	0.0866
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0021	0.0021
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0021	0.0509
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0021	0.0509
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0021	0.045
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0021	0.0021
Onchocerca volvulus		0.0012	0.0021	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Onchocerca volvulus		0.0012	0.0021	0.5
Schistosoma mansoni	amine GPCR	0.0012	0.0021	0.045
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0021	0.045
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0021	0.045
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0021	0.0021
Brugia malayi	G-protein coupled receptor	0.0012	0.0021	0.0509
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Onchocerca volvulus		0.0012	0.0021	0.5
Onchocerca volvulus		0.0012	0.0021	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0021	0.0021
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0021	0.0021
Echinococcus granulosus	somatostatin receptor	0.0012	0.0021	0.0021
Onchocerca volvulus		0.0012	0.0021	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.0021	0.045
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0021	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	serotonin receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Brugia malayi	larval opioid receptor	0.0012	0.0021	0.0509
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0021	0.0054
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0012	0.0021	0.045
Schistosoma mansoni	amine GPCR	0.0012	0.0021	0.045
Onchocerca volvulus		0.0012	0.0021	0.5
Schistosoma mansoni	hypothetical protein	0.0012	0.0021	0.045
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0021	0.0021
Schistosoma mansoni	amine GPCR	0.0012	0.0021	0.045
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0021	0.0509
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Schistosoma mansoni	hypothetical protein	0.0012	0.0021	0.045
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0407	1
Onchocerca volvulus		0.0012	0.0021	0.5
Schistosoma mansoni	amine GPCR	0.0012	0.0021	0.045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.025	0.3823	1
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0459	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.025	0.3823	1
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.025	0.3823	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0021	0.0054
Onchocerca volvulus		0.0012	0.0021	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.025	0.3823	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0021	0.0021
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0021	0.0509
Onchocerca volvulus		0.0012	0.0021	0.5
Echinococcus granulosus	hypothetical protein	0.0012	0.0021	0.0021
Brugia malayi	neuropeptide F receptor	0.0012	0.0021	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0021	0.0021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.0021	0.045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Toxoplasma gondii	hypothetical protein	0.025	0.3823	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0021	0.0509
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.0021	0.045
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	myosin xvIII	0.0012	0.0021	0.045
Onchocerca volvulus		0.0012	0.0021	0.5
Brugia malayi	Dopamine receptor	0.0012	0.0021	0.0509
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0021	0.045
Brugia malayi	Serotonin receptor	0.0012	0.0021	0.0509
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0021	0.0021
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Onchocerca volvulus		0.0012	0.0021	0.5
Onchocerca volvulus		0.0012	0.0021	0.5
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	opsin-like receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	serotonin receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0021	0.0021
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0021	0.0509
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0012	0.0021	0.5
Brugia malayi	RE15519p	0.0012	0.0021	0.0509
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.0021	0.045
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0021	0.045
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0021	0.045
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.0021	0.0021
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	opsin-like receptor	0.0012	0.0021	0.045
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0021	0.045
Brugia malayi	putative neuropeptide receptor	0.0012	0.0021	0.0509
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0021	0.0021
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0021	0.0509
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0021	0.0509
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0021	0.0509
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0021	0.0021
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0407	0.0407
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Brugia malayi	neuropeptide F receptor	0.0012	0.0021	0.0509
Echinococcus granulosus	sex peptide receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0021	0.0054
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0021	0.0054
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0021	0.0021
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0012	0.0021	0.5
Onchocerca volvulus		0.0012	0.0021	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0369	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0021	0.0054
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0369	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Brugia malayi	G protein-coupled receptor	0.0012	0.0021	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0021	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.0021	0.045
Brugia malayi	G-protein coupled receptor	0.0012	0.0021	0.0509
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	opsin-like receptor	0.0012	0.0021	0.045
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0407	0.1064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0021	0.045
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0021	0.0021
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0407	0.0407
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0021	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0021	0.045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0021	0.0021
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0021	0.0509
Brugia malayi	GnHR receptor homolog	0.0012	0.0021	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0021	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0021	0.045
Onchocerca volvulus		0.0012	0.0021	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0021	0.0021
Schistosoma mansoni	amine GPCR	0.0012	0.0021	0.045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.0021	0.045
Brugia malayi	AKH receptor	0.0012	0.0021	0.0509
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0021	0.0021
Onchocerca volvulus		0.0012	0.0021	0.5
Onchocerca volvulus		0.0012	0.0021	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0021	0.0021
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0021	0.0509
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0021	0.0021
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0021	0.0021
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0021	0.0021
Echinococcus multilocularis	serotonin receptor	0.0012	0.0021	0.0021
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0021	0.045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0021	0.0021
Schistosoma mansoni	adenoreceptor	0.0012	0.0021	0.045
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0021	0.0021
Brugia malayi	sulfakinin receptor protein	0.0012	0.0021	0.0509
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0021	0.0021
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0021	0.0021
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0012	0.0021	0.0509
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.0021	0.045
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.0021	0.045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0637	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0021	0.0021
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0054

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 56 %	Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells at 1 uM after 2 hrs by liquid scintillation counting	ChEMBL.	22464684
Activity (binding)	= 60 %	Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells at 1 uM after 2 hrs by liquid scintillation counting	ChEMBL.	22464684
Activity (binding)	= 64 %	Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells at 1 uM after 2 hrs by liquid scintillation counting	ChEMBL.	22464684
Ki (binding)	> 1000 nM	Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL.	22464684
Ki (binding)	> 1000 nM	Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL.	22464684
Ki (binding)	> 10000 nM	Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL.	22464684

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2022305

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1644457