Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (17-beta) dehydrogenase 3 | 310 aa | 256 aa | 32.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.4608 | 0.5 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.4608 | 0.5 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.4608 | 0.5 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.4608 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at human GR receptor expressed in human HeLa cells assessed as inhibition of DHT-induced response after 40 hrs by luciferase/beta-galactosidase-based reporter gene assay | ChEMBL. | 22512907 | |
Activity (functional) | Antagonist activity at human ERalpha receptor expressed in human HeLa cells assessed as inhibition of DHT-induced response after 40 hrs by luciferase/beta-galactosidase-based reporter gene assay | ChEMBL. | 22512907 | |
Activity (functional) | Agonist activity at human Glucocorticoid receptor expressed in human HeLa cells assessed as DHT-induced response after 40 hrs by luciferase/beta-galactosidase-based reporter gene assay | ChEMBL. | 22512907 | |
Activity (functional) | Agonist activity at human Estrogen receptor ERalpha expressed in human HeLa cells assessed as DHT-induced response after 40 hrs by luciferase/beta-galactosidase-based reporter gene assay | ChEMBL. | 22512907 | |
IC50 (binding) | = 190 nM | Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry | ChEMBL. | 22512907 |
Inhibition (binding) | Inhibition of human recombinant 17-beta-HSD2 expressed in human HeLa cells using estradiol as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry | ChEMBL. | 22512907 | |
Inhibition (binding) | Inhibition of human recombinant 17-beta-HSD1 expressed in human HeLa cells using estrone as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry | ChEMBL. | 22512907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.