Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | GTOR | 0.0929 | 0.1162 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.5629 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0929 | 0.1162 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.5629 | 1 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0929 | 0.1162 | 0.1162 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0501 | 0.0356 | 0.3066 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0929 | 0.1162 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0555 | 0.0458 | 0.3945 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0739 | 0.0804 | 0.6922 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0929 | 0.1162 | 0.1162 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0502 | 0.0358 | 0.3078 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.074 | 0.0806 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0502 | 0.0358 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0502 | 0.0358 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.5629 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0623 | 0.0586 | 0.5047 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.5629 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0603 | 0.0549 | 0.4722 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.074 | 0.0806 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0386 | 0.014 | 0.1204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0793 | 0.0906 | 0.78 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.055 | 0.0448 | 0.3855 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0555 | 0.0458 | 0.3945 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0739 | 0.0804 | 0.6922 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0555 | 0.0458 | 0.3945 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0739 | 0.0804 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0501 | 0.0356 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0739 | 0.0804 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.055 | 0.0448 | 0.3855 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0929 | 0.1162 | 0.1162 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0501 | 0.0356 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.074 | 0.0806 | 0.6934 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0929 | 0.1162 | 0.5 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0739 | 0.0804 | 0.6922 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0439 | 0.024 | 0.207 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0929 | 0.1162 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0691 | 0.0714 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0502 | 0.0358 | 0.3078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.722 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.66 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.638 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.607 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.534 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.379 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.362 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.35 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.302 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.