Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol transporter | 2.1175 | 1 | 1 |
Onchocerca volvulus | 0.5403 | 0 | 0.5 | |
Schistosoma mansoni | inositol transporter | 2.1175 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 2.1175 | 1 | 1 |
Brugia malayi | GH02984p | 0.5403 | 0 | 0.5 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.5403 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5403 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 5 | 2.1175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5403 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 2.1175 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 2.1175 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 2.1175 | 1 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.5403 | 0 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 2.1175 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.455 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.