Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cytochrome P450 19A1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 450 aa | 21.1 % |
Dictyostelium discoideum | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 465 aa | 21.5 % |
Drosophila melanogaster | Cytochrome P450-4d1 | Cytochrome P450 19A1 | 508 aa | 464 aa | 24.6 % |
Brugia malayi | Cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 448 aa | 20.8 % |
Dictyostelium discoideum | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 473 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0116 | 0 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0293 | 0.2093 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0116 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0293 | 0.2093 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0293 | 0.2093 | 0.5992 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0961 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0293 | 0.2093 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0293 | 0.2093 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0293 | 0.2093 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0293 | 0.2093 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0293 | 0.2093 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0293 | 0.2093 | 0.5992 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0293 | 0.2093 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0293 | 0.2093 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0961 | 1 | 1 |
Plasmodium vivax | PST-A protein | 0.0293 | 0.2093 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0116 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0293 | 0.2093 | 0.6129 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0961 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0293 | 0.2093 | 1 |
Plasmodium falciparum | esterase, putative | 0.0293 | 0.2093 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0293 | 0.2093 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0961 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0293 | 0.2093 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0293 | 0.2093 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0293 | 0.2093 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0404 | 0.3415 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0293 | 0.2093 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0293 | 0.2093 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0293 | 0.2093 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0293 | 0.2093 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0961 | 1 | 1 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0411 | 0.3493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0961 | 1 | 1 |
Schistosoma mansoni | amidase | 0.0961 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.