Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1886 | 0.19 |
Brugia malayi | hypothetical protein | 0.018 | 0.1886 | 0.19 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0034 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0802 | 0.993 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0802 | 0.993 | 1 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0034 | 0 | 0.5 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0802 | 0.993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1886 | 0.19 |
Onchocerca volvulus | 0.018 | 0.1886 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0034 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0 | 0.5 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0034 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.755 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.613 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.589 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.498 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.269 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.