TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.448 | Formula: C20H18N4O2S
H donors: 2 H acceptors: 3 LogP: 3.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N=C1SC(c2ccc(cc2)O)c2c(N1)n(nc2C)C(=O)Cc1ccccc1
InChi: 1S/C20H18N4O2S/c1-12-17-18(14-7-9-15(25)10-8-14)27-20(21)22-19(17)24(23-12)16(26)11-13-5-3-2-4-6-13/h2-10,18,25H,11H2,1H3,(H2,21,22)
InChiKey: KZIIHHQRCNRCIL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0303	0.9337	1
Echinococcus granulosus	g protein coupled receptor	0.0303	0.9337	1
Brugia malayi	Dopamine receptor protein 1	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	G protein-coupled receptor F59B2.13	0.0303	0.9337	1
Brugia malayi	follicle stimulating hormone receptor	0.0303	0.9337	1
Echinococcus granulosus	fmrfamide receptor	0.0303	0.9337	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0303	0.9337	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0303	0.9337	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0303	0.9337	1
Brugia malayi	ORL1-like opioid receptor	0.0303	0.9337	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0303	0.9337	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Onchocerca volvulus		0.0303	0.9337	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0303	0.9337	1
Echinococcus multilocularis	somatostatin receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	biogenic amine receptor	0.0303	0.9337	1
Schistosoma mansoni	amine GPCR	0.0303	0.9337	1
Schistosoma mansoni	hypothetical protein	0.0303	0.9337	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0303	0.9337	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Schistosoma mansoni	growth hormone secretagogue receptor	0.0303	0.9337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.8998	0.8998
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Schistosoma mansoni	biogenic amine receptor	0.0303	0.9337	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0303	0.9337	0.9594
Onchocerca volvulus		0.0303	0.9337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	G protein coupled receptor 139	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0303	0.9337	1
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0303	0.9337	0.9337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Schistosoma mansoni	amine GPCR	0.0303	0.9337	1
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0314	0.9731	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	neuropeptide receptor	0.0303	0.9337	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.6205	0.6205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Echinococcus multilocularis	g protein coupled receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	neuropeptide receptor	0.0303	0.9337	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0303	0.9337	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	serotonin receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	histamine h1 receptor	0.0303	0.9337	1
Schistosoma mansoni	neuropeptide receptor	0.0303	0.9337	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	neuropeptide Y receptor	0.0303	0.9337	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0303	0.9337	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Schistosoma mansoni	biogenic amine receptor	0.0303	0.9337	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0303	0.9337	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0303	0.9337	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0303	0.9337	0.9337
Brugia malayi	G-protein coupled receptor	0.0303	0.9337	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0303	0.9337	0.9337
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Brugia malayi	Melatonin receptor type 1A	0.0303	0.9337	1
Echinococcus granulosus	neuropeptide receptor A26	0.0303	0.9337	1
Schistosoma mansoni	adenoreceptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Loa Loa (eye worm)	TYRA-2 protein	0.0303	0.9337	0.9337
Schistosoma mansoni	hypothetical protein	0.0303	0.9337	1
Brugia malayi	neuropeptide F receptor	0.0303	0.9337	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0303	0.9337	0.9337
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0303	0.9337	0.9594
Echinococcus granulosus	hypothetical protein	0.0303	0.9337	1
Schistosoma mansoni	hypothetical protein	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Loa Loa (eye worm)	G-protein coupled receptor	0.0303	0.9337	0.9337
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0303	0.9337	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	orexin receptor type 2	0.0303	0.9337	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0303	0.9337	1
Echinococcus granulosus	neuropeptide s receptor	0.0303	0.9337	1
Brugia malayi	RE15519p	0.0303	0.9337	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	neuropeptide receptor	0.0303	0.9337	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0303	0.9337	1
Brugia malayi	putative neuropeptide receptor	0.0303	0.9337	1
Echinococcus multilocularis	sex peptide receptor	0.0303	0.9337	0.9594
Echinococcus granulosus	somatostatin receptor	0.0303	0.9337	1
Brugia malayi	G-protein coupled receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Schistosoma mansoni	amine GPCR	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0303	0.9337	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0303	0.9337	0.9594
Brugia malayi	neuropeptide F receptor	0.0303	0.9337	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0303	0.9337	0.9594
Echinococcus multilocularis	neuropeptide Y receptor	0.0303	0.9337	0.9594
Brugia malayi	putative neuropeptide receptor NPR1	0.0303	0.9337	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0303	0.9337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	g protein coupled receptor	0.0303	0.9337	1
Schistosoma mansoni	hypothetical protein	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0303	0.9337	1
Brugia malayi	Dopamine receptor	0.0303	0.9337	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0303	0.9337	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0303	0.9337	1
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0206	0.5936	0.6358
Echinococcus multilocularis	orexin receptor type 2	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	G protein-coupled receptor	0.0303	0.9337	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0303	0.9337	1
Echinococcus granulosus	g-protein coupled receptor	0.0303	0.9337	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0303	0.9337	0.9337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0303	0.9337	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0303	0.9337	0.9594
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0303	0.9337	0.9594
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0303	0.9337	0.9594
Schistosoma mansoni	myosin xvIII	0.0303	0.9337	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0303	0.9337	0.9337
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0303	0.9337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	fmrfamide receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	neuropeptide Y receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0303	0.9337	1
Echinococcus multilocularis	g protein coupled receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Brugia malayi	AKH receptor	0.0303	0.9337	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0303	0.9337	0.9594
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0303	0.9337	0.9594
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0303	0.9337	1
Echinococcus multilocularis	neuropeptide receptor	0.0303	0.9337	0.9594
Echinococcus multilocularis	G protein coupled receptor 139	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	allatostatin A receptor	0.0303	0.9337	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0303	0.9337	0.9594
Loa Loa (eye worm)	melatonin receptor type 1A	0.0303	0.9337	0.9337
Echinococcus granulosus	biogenic amine 5HT receptor	0.0303	0.9337	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Schistosoma mansoni	opsin-like receptor	0.0303	0.9337	1
Schistosoma mansoni	amine GPCR	0.0303	0.9337	1
Echinococcus multilocularis	serotonin receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	dro:myosuppressin receptor	0.0303	0.9337	0.9594
Onchocerca volvulus		0.0303	0.9337	0.5
Brugia malayi	GnHR receptor homolog	0.0303	0.9337	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0303	0.9337	1
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Brugia malayi	Serotonin receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0303	0.9337	0.9594
Echinococcus granulosus	neuropeptide Y receptor	0.0303	0.9337	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0303	0.9337	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Loa Loa (eye worm)	G-protein coupled receptor	0.0303	0.9337	0.9337
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0303	0.9337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus granulosus	sex peptide receptor	0.0303	0.9337	1
Schistosoma mansoni	amine GPCR	0.0303	0.9337	1
Schistosoma mansoni	neuropeptide receptor	0.0303	0.9337	1
Brugia malayi	Serotonin receptor	0.0303	0.9337	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0303	0.9337	0.9594
Echinococcus granulosus	neuropeptides capa receptor	0.0303	0.9337	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0303	0.9337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Onchocerca volvulus		0.0303	0.9337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0303	0.9337	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0303	0.9337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0303	0.9337	1
Echinococcus multilocularis	g protein coupled receptor	0.0303	0.9337	0.9594
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0303	0.9337	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0303	0.9337	0.9337
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Brugia malayi	larval opioid receptor	0.0303	0.9337	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0303	0.9337	1
Schistosoma mansoni	neuropeptide receptor	0.0303	0.9337	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0303	0.9337	1
Brugia malayi	hypothetical protein	0.0303	0.9337	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0303	0.9337	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	sulfakinin receptor protein	0.0303	0.9337	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0303	0.9337	1
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0303	0.9337	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0303	0.9337	0.9594
Echinococcus granulosus	7TM GPCR rhodopsin	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Onchocerca volvulus		0.0303	0.9337	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0303	0.9337	0.9594
Brugia malayi	Dopamine receptor protein 2	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Onchocerca volvulus		0.0303	0.9337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus multilocularis	fmrfamide receptor	0.0303	0.9337	0.9594
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0303	0.9337	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337
Echinococcus granulosus	serotonin receptor	0.0303	0.9337	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9337	0.9337

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 96 %	Cytotoxicity against human MCF7 cells assessed as viable cells at 10 uM by trypan blue staining based assay	ChEMBL.	26840362
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1987615

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1647460