Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0084 | 0.0621 | 0.0621 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0728 | 0.8966 | 0.8966 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0808 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0728 | 0.8966 | 0.8966 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0808 | 1 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.0084 | 0.0621 | 0.0621 |
Echinococcus multilocularis | lysosomal protective protein | 0.0808 | 1 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0808 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0808 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0417 | 0.0417 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.008 | 0.0569 | 0.0569 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | jun protein | 0.0084 | 0.0621 | 0.0621 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0808 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0808 | 1 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.0417 | 0.0417 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0084 | 0.0621 | 0.0621 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0084 | 0.0621 | 0.0621 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0808 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0388 | 0.0388 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0808 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.548 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.528 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.372 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.285 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.28 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.21 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.073 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.