Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0551 | 0.0232 | 0.0232 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.1585 | 0.4584 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0621 | 0.0528 | 0.1152 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0621 | 0.0528 | 0.1152 |
Echinococcus granulosus | tissue type plasminogen activator | 0.1585 | 0.4584 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0621 | 0.0528 | 0.1152 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.1585 | 0.4584 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2764 | 0.9541 | 0.9541 |
Schistosoma mansoni | hypothetical protein | 0.1585 | 0.4584 | 0.4584 |
Echinococcus granulosus | Mastin | 0.0621 | 0.0528 | 0.1152 |
Loa Loa (eye worm) | hypothetical protein | 0.1585 | 0.4584 | 0.4804 |
Echinococcus multilocularis | enteropeptidase | 0.0621 | 0.0528 | 0.1152 |
Loa Loa (eye worm) | hypothetical protein | 0.2764 | 0.9541 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1585 | 0.4584 | 0.5 |
Onchocerca volvulus | 0.2764 | 0.9541 | 1 | |
Onchocerca volvulus | 0.2268 | 0.7456 | 0.7814 | |
Onchocerca volvulus | 0.1585 | 0.4584 | 0.4804 | |
Brugia malayi | Kringle domain containing protein | 0.1585 | 0.4584 | 0.4804 |
Mycobacterium ulcerans | hypothetical protein | 0.0496 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.2764 | 0.9541 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0621 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.2764 | 0.9541 | 1 |
Echinococcus multilocularis | Mastin | 0.0621 | 0.0528 | 0.1152 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.1585 | 0.4584 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1585 | 0.4584 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.1585 | 0.4584 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.1585 | 0.4584 | 0.4804 |
Brugia malayi | Protein kinase domain containing protein | 0.1585 | 0.4584 | 0.4804 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.879 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.825 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.776 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.773 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.733 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.704 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.668 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.65 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.609 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.516 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.