Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0342 | 0.1776 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0342 | 0.1776 | 0.1491 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0124 | 0.0334 | 0.0724 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0342 | 0.1776 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0124 | 0.0334 | 0.0615 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0342 | 0.1776 | 0.3266 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0124 | 0.0334 | 0.0615 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0124 | 0.0334 | 0.0615 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0133 | 0.0398 | 0.0731 |
Schistosoma mansoni | hypothetical protein | 0.0771 | 0.4618 | 0.8493 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0124 | 0.0334 | 0.0724 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0124 | 0.0334 | 0.0615 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0342 | 0.1776 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0342 | 0.1776 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0342 | 0.1776 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1527 | 0.9613 | 0.96 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0342 | 0.1776 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0124 | 0.0334 | 0.0615 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0124 | 0.0334 | 0.0615 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0771 | 0.4618 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0124 | 0.0334 | 0.0615 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0342 | 0.1776 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0124 | 0.0334 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0124 | 0.0334 | 0.0615 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0124 | 0.0334 | 0.0615 |
Leishmania major | dihydroorotate dehydrogenase | 0.0342 | 0.1776 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1404 | 0.1107 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0124 | 0.0334 | 0.0615 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0124 | 0.0334 | 0.0724 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0342 | 0.1776 | 0.1491 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0133 | 0.0398 | 0.0066 |
Schistosoma mansoni | nuclear hormone receptor | 0.0124 | 0.0334 | 0.0615 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0124 | 0.0334 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0895 | 0.5438 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0124 | 0.0334 | 0.0615 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1527 | 0.9613 | 0.96 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0124 | 0.0334 | 0.0615 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0124 | 0.0334 | 0.0615 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0342 | 0.1776 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0124 | 0.0334 | 0.0615 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0124 | 0.0334 | 0.0615 |
Onchocerca volvulus | 0.0124 | 0.0334 | 0.5 | |
Echinococcus granulosus | FTZ F1 alpha | 0.0124 | 0.0334 | 0.0724 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0342 | 0.1776 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0124 | 0.0334 | 0.0615 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0133 | 0.0398 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.152 | 0.9567 | 0.995 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1404 | 0.304 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0124 | 0.0334 | 0.0724 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0133 | 0.0398 | 0.0731 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0124 | 0.0334 | 0.0724 |
Schistosoma mansoni | thyroid hormone receptor | 0.0895 | 0.5438 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0342 | 0.1776 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.1527 | 0.9613 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1404 | 0.1153 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0124 | 0.0334 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1404 | 0.2582 |
Schistosoma mansoni | thyroid hormone receptor | 0.0895 | 0.5438 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0124 | 0.0334 | 0.0724 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0124 | 0.0334 | 0.0615 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0124 | 0.0334 | 0.0724 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0124 | 0.0334 | 0.0724 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0133 | 0.0398 | 0.0861 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0771 | 0.4618 | 0.8493 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0124 | 0.0334 | 0.0615 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0133 | 0.0398 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0342 | 0.1776 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.