Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0382 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0382 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3666 | 0.3666 |
Echinococcus multilocularis | geminin | 0.0169 | 0.3666 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0382 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 1 | 0.5 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0382 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 1 | 0.5 | |
Echinococcus granulosus | geminin | 0.0169 | 0.3666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 1 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3666 | 0.3666 |
Schistosoma mansoni | tyrosinase precursor | 0.0382 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0382 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 1 | 0.5 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0382 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0382 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.825 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.