Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0063 | 0.0936 | 0.0952 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.04 | 0.9829 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.9829 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.9829 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0197 | 0.4467 | 0.4545 |
Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.0417 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0063 | 0.0936 | 0.0952 |
Leishmania major | cytochrome p450-like protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.4064 | 0.4135 |
Onchocerca volvulus | 0.0043 | 0.0417 | 0.5 | |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0819 | 0.0834 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.4064 | 0.4135 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.0417 | 0.0424 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.04 | 0.9829 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.4467 | 0.4545 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.04 | 0.9829 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.04 | 0.9829 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.827 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.826 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.778 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.738 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.736 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.715 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.689 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.618 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.617 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.53 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.