Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0156 | 0.031 | 0.011 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2786 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0149 | 0.0283 | 0.0477 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2786 | 1 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0642 | 0.2099 | 0.1846 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0109 | 0.0135 | 0.0153 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0764 | 0.0573 |
Giardia lamblia | GTOR | 0.0156 | 0.031 | 0.4749 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2786 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0127 | 0.0201 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0156 | 0.031 | 0.0109 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0156 | 0.031 | 0.0262 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0149 | 0.0283 | 0.0083 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Echinococcus multilocularis | thymidylate synthase | 0.2786 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0427 | 0.1306 | 0.1127 |
Echinococcus multilocularis | neuropeptide receptor | 0.0223 | 0.0555 | 0.0253 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0127 | 0.0201 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0156 | 0.031 | 0.0536 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0149 | 0.0283 | 0.0283 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0296 | 0.0825 | 0.1667 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0341 | 0.0992 | 0.6931 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0794 | 0.2661 | 0.2426 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2786 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0427 | 0.1306 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0642 | 0.2099 | 0.1846 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2786 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0149 | 0.0283 | 0.0477 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0156 | 0.031 | 0.0536 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0223 | 0.0555 | 0.0253 |
Loa Loa (eye worm) | thymidylate synthase | 0.2786 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.009 | 0.0066 | 0.0001 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0156 | 0.031 | 0.031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1325 | 0.4618 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0156 | 0.031 | 0.0536 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0127 | 0.0202 | 0.0202 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0211 | 0.0511 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0794 | 0.2661 | 0.2426 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0098 | 0.0097 | 0.0068 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0156 | 0.031 | 0.0028 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.009 | 0.0066 | 0.0001 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0427 | 0.1306 | 0.2725 |
Entamoeba histolytica | hypothetical protein | 0.0341 | 0.0992 | 0.6931 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0106 | 0.0124 | 0.0128 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0127 | 0.0203 | 0.0001 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0709 | 0.2346 | 0.2188 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.009 | 0.0066 | 0.0001 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0135 | 0.0232 | 0.0366 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0127 | 0.0201 | 0.0298 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.028 | 0.0764 | 0.0469 |
Onchocerca volvulus | 0.2786 | 1 | 0.5 | |
Brugia malayi | hypothetical protein | 0.1325 | 0.4618 | 0.4461 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0156 | 0.031 | 0.0028 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.008 | 0.0031 | 0.0031 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0427 | 0.1306 | 0.1053 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0794 | 0.2661 | 0.2447 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2786 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0405 | 0.1226 | 0.9221 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0156 | 0.031 | 0.0262 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0098 | 0.0097 | 0.0068 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0156 | 0.031 | 0.011 |
Schistosoma mansoni | neuropeptide receptor | 0.0223 | 0.0555 | 0.028 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0119 | 0.0174 | 0.0238 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.009 | 0.0066 | 0.0001 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2786 | 1 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0427 | 0.1306 | 0.2725 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0149 | 0.0283 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0276 | 0.0074 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2786 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.2786 | 1 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0427 | 0.1306 | 0.1127 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0127 | 0.0201 | 0.0298 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0368 | 0.1089 | 0.0829 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0156 | 0.031 | 0.031 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.028 | 0.0764 | 0.0469 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2786 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0097 | 0.0093 | 0.0061 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0098 | 0.0097 | 0.0068 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0296 | 0.0825 | 0.1667 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0194 | 0.045 | 0.1637 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0097 | 0.0093 | 0.0061 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1325 | 0.4618 | 0.4507 |
Echinococcus granulosus | neuropeptide receptor | 0.0223 | 0.0555 | 0.0253 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0156 | 0.031 | 0.011 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0156 | 0.031 | 0.011 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0427 | 0.1306 | 0.2725 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0127 | 0.0201 | 0.0298 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.028 | 0.0764 | 0.0496 |
Echinococcus granulosus | thymidylate synthase | 0.2786 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.72 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.573 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.555 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.376 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.327 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.252 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.217 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.103 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.101 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.