Detailed information for compound 1651850

Basic information

Technical information
  • TDR Targets ID: 1651850
  • Name: 3-[(4E)-4-[(4-hydroxyphenyl)methylidene]-5-ox o-2-phenylimidazol-1-yl]-2-phenylquinazolin-4 -one
  • MW: 484.505 | Formula: C30H20N4O3
  • H donors: 1 H acceptors: 3 LogP: 5.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)/C=C\1/N=C(N(C1=O)n1c(nc2c(c1=O)cccc2)c1ccccc1)c1ccccc1
  • InChi: 1S/C30H20N4O3/c35-23-17-15-20(16-18-23)19-26-30(37)34(28(32-26)22-11-5-2-6-12-22)33-27(21-9-3-1-4-10-21)31-25-14-8-7-13-24(25)29(33)36/h1-19,35H/b26-19+
  • InChiKey: PVFYZPXAJJHLJN-LGUFXXKBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(4E)-4-[(4-hydroxyphenyl)methylene]-5-oxo-2-phenyl-imidazol-1-yl]-2-phenyl-quinazolin-4-one
  • 3-[(4E)-4-[(4-hydroxyphenyl)methylene]-5-oxo-2-phenyl-1-imidazolyl]-2-phenyl-4-quinazolinone
  • 3-[(4E)-4-(4-hydroxybenzylidene)-5-keto-2-phenyl-imidazol-1-yl]-2-phenyl-quinazolin-4-one
  • 3-[(4E)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-2-phenyl-imidazol-1-yl]-2-phenyl-quinazolin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.2995 0.5369
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.21 0.3464
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0083 0.21 0.3464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.21 0.406
Echinococcus multilocularis g protein coupled receptor 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0756 0.1773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0756 0.2217
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Brugia malayi map kinase activated protein kinase protein 2 0.0175 0.5172 1
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.21 0.3464
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis fmrfamide receptor 0.0083 0.21 0.3464
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.2995 0.5369
Echinococcus multilocularis serotonin receptor 0.0083 0.21 0.3464
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.21 0.3464
Schistosoma mansoni biogenic amine receptor 0.0083 0.21 0.406
Brugia malayi sulfakinin receptor protein 0.0083 0.21 0.406
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.069 0.1333
Echinococcus multilocularis G-protein coupled receptor, putative 0.0083 0.21 0.3464
Schistosoma mansoni hypothetical protein 0.0083 0.21 0.406
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.2995 0.5
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.2995 0.5
Schistosoma mansoni amine GPCR 0.0083 0.21 0.406
Brugia malayi follicle stimulating hormone receptor 0.0083 0.21 0.406
Echinococcus multilocularis somatostatin receptor 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Brugia malayi Dopamine receptor 0.0083 0.21 0.406
Schistosoma mansoni opsin-like receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus hypothetical protein 0.0083 0.21 0.3464
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0175 0.5172 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.21 0.3464
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0083 0.21 0.406
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0083 0.21 0.3464
Schistosoma mansoni amine GPCR 0.0083 0.21 0.406
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0083 0.21 0.1794
Echinococcus granulosus sex peptide receptor 0.0083 0.21 0.3464
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0083 0.21 0.3464
Schistosoma mansoni neuropeptide receptor 0.0083 0.21 0.406
Loa Loa (eye worm) TYRA-2 protein 0.0083 0.21 0.1794
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.21 0.3464
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.2995 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0083 0.21 0.3464
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus neuropeptide FF receptor 2 0.0083 0.21 0.3464
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.21 0.406
Brugia malayi 6-phosphofructokinase 0.0109 0.2995 0.5791
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.5172 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0083 0.21 0.3464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0756 0.1773
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.21 0.3464
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0083 0.21 0.3464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Brugia malayi G-protein coupled receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni opsin-like receptor 0.0083 0.21 0.406
Echinococcus granulosus allatostatin A receptor 0.0083 0.21 0.3464
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0083 0.21 0.406
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.21 0.3464
Brugia malayi neuropeptide F receptor 0.0083 0.21 0.406
Schistosoma mansoni chromobox protein 0.007 0.1684 0.3256
Brugia malayi larval opioid receptor 0.0083 0.21 0.406
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0083 0.21 1
Echinococcus multilocularis orexin receptor type 2 0.0083 0.21 0.3464
Loa Loa (eye worm) melatonin receptor type 1A 0.0083 0.21 0.1794
Schistosoma mansoni hypothetical protein 0.0083 0.21 0.406
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0656 0.1407
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.21 0.3464
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0331 0.0212
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0331 0.5
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni myosin xvIII 0.0083 0.21 0.406
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0563 0.1089
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0083 0.21 0.406
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0656 0.1641
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.2995 0.5
Schistosoma mansoni biogenic amine receptor 0.0083 0.21 0.406
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi AKH receptor 0.0083 0.21 0.406
Onchocerca volvulus 0.0083 0.21 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0083 0.21 0.3464
Echinococcus multilocularis serotonin receptor 0.0083 0.21 0.3464
Onchocerca volvulus Neuropeptide F receptor homolog 0.0083 0.21 1
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2995 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0331 0.0212
Onchocerca volvulus 0.0083 0.21 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi Serotonin receptor 0.0083 0.21 0.406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi neuropeptide F receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0083 0.21 0.406
Echinococcus granulosus 7tm_1 domain containing protein 0.0083 0.21 0.3464
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0471 0.0911
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Echinococcus multilocularis neuropeptide FF receptor 2 0.0083 0.21 0.3464
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0083 0.21 0.406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Schistosoma mansoni growth hormone secretagogue receptor 0.0083 0.21 0.406
Onchocerca volvulus 0.0083 0.21 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi Tachykinin-like peptides receptor 99D 0.0083 0.21 0.406
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2995 1
Echinococcus granulosus neuropeptide s receptor 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0083 0.21 0.406
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0331 0.5
Echinococcus granulosus orexin receptor type 2 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0083 0.21 0.3464
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0083 0.21 0.406
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Brugia malayi phosphofructokinase 0.0109 0.2995 0.5791
Echinococcus granulosus alpha 1A adrenergic receptor 0.0083 0.21 0.3464
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.21 0.1794
Brugia malayi putative neuropeptide receptor 0.0083 0.21 0.406
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.21 0.406
Schistosoma mansoni amine GPCR 0.0083 0.21 0.406
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.21 0.1794
Echinococcus granulosus chromobox protein 1 0.007 0.1684 0.258
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0083 0.21 0.406
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0083 0.21 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Schistosoma mansoni alpha-1 adrenergic receptor 0.0083 0.21 0.406
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.2995 0.5791
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0175 0.5172 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus neuropeptide receptor 0.0083 0.21 0.3464
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0331 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0083 0.21 0.406
Brugia malayi Heterochromatin protein 1 0.007 0.1684 0.3256
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0083 0.21 0.3464
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.1001 0.1126
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0083 0.21 0.406
Echinococcus granulosus somatostatin receptor 0.0083 0.21 0.3464
Echinococcus granulosus g protein coupled receptor 0.0083 0.21 0.3464
Schistosoma mansoni hypothetical protein 0.0083 0.21 0.406
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.21 0.3464
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0083 0.21 0.406
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0331 0.0212
Schistosoma mansoni opsin-like receptor 0.0083 0.21 0.406
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni biogenic amine receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.21 0.3464
Echinococcus multilocularis allatostatin A receptor 0.0083 0.21 0.3464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Brugia malayi G-protein coupled receptor 0.0083 0.21 0.406
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.21 0.1794
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Onchocerca volvulus 0.0083 0.21 1
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.21 0.3464
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0083 0.21 0.3464
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.21 0.3464
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.1001 0.1126
Onchocerca volvulus 0.0083 0.21 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Onchocerca volvulus 0.0083 0.21 1
Echinococcus granulosus dro:myosuppressin receptor 0.0083 0.21 0.3464
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.21 0.3464
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.21 0.3464
Brugia malayi RE15519p 0.0083 0.21 0.406
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Onchocerca volvulus 0.0083 0.21 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi 6-phosphofructokinase 0.0109 0.2995 0.5791
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2995 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0083 0.21 0.406
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0656 0.1407
Brugia malayi chromobox protein homolog 3 0.0039 0.0656 0.1268
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Loa Loa (eye worm) phosphofructokinase 0.0109 0.2995 0.2724
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0083 0.21 0.3464
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.2995 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0083 0.21 0.3464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Brugia malayi hypothetical protein 0.0122 0.3433 0.6637
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0083 0.21 0.1794
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2995 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0083 0.21 0.3464
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0083 0.21 0.3464
Schistosoma mansoni neuropeptide receptor 0.0083 0.21 0.406
Brugia malayi Dopamine receptor protein 2 0.0083 0.21 0.406
Echinococcus multilocularis dro:myosuppressin receptor 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0331 0.0212
Schistosoma mansoni neuropeptide receptor 0.0083 0.21 0.406
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0331 0.5
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus g protein coupled receptor 0.0083 0.21 0.3464
Schistosoma mansoni chromobox protein 0.007 0.1684 0.3256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.005 0.1001 0.0652
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Echinococcus granulosus chromobox protein 1 0.007 0.1684 0.258
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0083 0.21 0.1794
Echinococcus granulosus g-protein coupled receptor 0.0083 0.21 0.3464
Brugia malayi G protein-coupled receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.21 0.3464
Echinococcus multilocularis sex peptide receptor 0.0083 0.21 0.3464
Echinococcus multilocularis chromobox protein 1 0.007 0.1684 0.258
Brugia malayi ORL1-like opioid receptor 0.0083 0.21 0.406
Onchocerca volvulus 0.0083 0.21 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.2995 0.5791
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1684 0.1363
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0083 0.21 0.1794
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.21 0.1794
Loa Loa (eye worm) glutamate receptor 0.004 0.069 0.0329
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0874 0.169
Echinococcus granulosus fmrfamide receptor 0.0083 0.21 0.3464
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0331 0.0212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.21 0.406
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis neuropeptide s receptor 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus granulosus serotonin receptor 0.0083 0.21 0.3464
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.21 0.3464
Echinococcus granulosus g protein coupled receptor 0.0083 0.21 0.3464
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0175 0.5172 0.4985
Schistosoma mansoni adenoreceptor 0.0083 0.21 0.406
Echinococcus multilocularis g protein coupled receptor 0.0083 0.21 0.3464
Loa Loa (eye worm) hypothetical protein 0.0039 0.0656 0.0294
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0083 0.21 0.3464
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0083 0.21 0.406
Schistosoma mansoni hypothetical protein 0.0083 0.21 0.406
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2995 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0083 0.21 0.406
Echinococcus multilocularis chromobox protein 1 0.007 0.1684 0.258
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.21 0.3464
Echinococcus multilocularis g-protein coupled receptor 0.0083 0.21 0.3464
Trichomonas vaginalis chromobox protein, putative 0.007 0.1684 0.5185
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Onchocerca volvulus 0.0083 0.21 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0083 0.21 0.406
Brugia malayi Serotonin receptor 0.0083 0.21 0.406
Brugia malayi putative neuropeptide receptor NPR1 0.0083 0.21 0.406
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0331 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0083 0.21 0.3464
Echinococcus multilocularis G protein coupled receptor 139 0.0083 0.21 0.3464
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0331 0.0212
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2995 1
Brugia malayi hypothetical protein 0.0083 0.21 0.406
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2995 1
Brugia malayi GnHR receptor homolog 0.0083 0.21 0.406
Schistosoma mansoni neuropeptide receptor 0.0083 0.21 0.406
Echinococcus granulosus neuropeptide receptor A26 0.0083 0.21 0.3464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.21 0.406
Schistosoma mansoni histamine h1 receptor 0.0083 0.21 0.406
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.2995 0.5
Brugia malayi Melatonin receptor type 1A 0.0083 0.21 0.406
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0331 0.0212
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0331 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.21 0.3464
Onchocerca volvulus 0.0083 0.21 1
Echinococcus multilocularis g protein coupled receptor 0.0083 0.21 0.3464
Echinococcus multilocularis neuropeptide receptor 0.0083 0.21 0.3464
Trichomonas vaginalis chromobox protein, putative 0.007 0.1684 0.5185
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.2995 0.2724
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.21 0.3464
Schistosoma mansoni amine GPCR 0.0083 0.21 0.406
Brugia malayi Dopamine receptor protein 1 0.0083 0.21 0.406
Echinococcus granulosus neuropeptide receptor 0.0083 0.21 0.3464
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0331 0.5
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.2995 0.5
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni amine GPCR 0.0083 0.21 0.406
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0331 0.5
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0331 0.5
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0331 0.5
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.2995 0.2724
Loa Loa (eye worm) hypothetical protein 0.0083 0.21 0.1794
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.21 0.406
Echinococcus granulosus G protein coupled receptor 139 0.0083 0.21 0.3464
Echinococcus multilocularis fmrfamide receptor 0.0083 0.21 0.3464
Echinococcus multilocularis neuropeptide receptor 0.0083 0.21 0.3464

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.391 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.145 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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