Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.00503189 | 0.00471266 | 0.5 |
Echinococcus granulosus | folate receptor beta | 0.225296 | 1 | 1 |
Onchocerca volvulus | 0.0300699 | 0.117849 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0224387 | 0.0833671 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0872386 | 0.376172 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0300699 | 0.117849 | 1 |
Brugia malayi | Reduced folate carrier family protein | 0.0300699 | 0.117849 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0300699 | 0.117849 | 1 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0300699 | 0.117849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Onchocerca volvulus | 0.0300699 | 0.117849 | 1 | |
Onchocerca volvulus | 0.0300699 | 0.117849 | 1 | |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0224387 | 0.0833671 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Onchocerca volvulus | 0.0300699 | 0.117849 | 1 | |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0224387 | 0.0833671 | 1 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.0300699 | 0.117849 | 0.5 |
Brugia malayi | folate-like transporter 3 | 0.0300699 | 0.117849 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0429703 | 0.176141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.225296 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0300699 | 0.117849 | 0.5 |
Onchocerca volvulus | 0.00503189 | 0.00471266 | 0.0399889 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 15.015 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 incubated for 72 hrs by DNA staining based MARK1 growth inhibition assay | ChEMBL. | 22727641 |
EC50 (ADMET) | > 26.0417 uM | Cytotoxicity against human HepG2 cells after 72 hrs by resazurin dye based CellTiterGlo reagent assay | ChEMBL. | 22727641 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22727641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.