Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 1 | 0.5 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0561 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0561 | 1 | 0.5 |
Onchocerca volvulus | 0.0561 | 1 | 0.5 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0561 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0561 | 1 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0147 | 0.21 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0561 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0147 | 0.21 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 1 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0561 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0561 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.504 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.504 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0561 | 1 | 0.5 | |
Onchocerca volvulus | 0.0561 | 1 | 0.5 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0301 | 0.504 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0561 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0147 | 0.21 | 0.5 |
Onchocerca volvulus | 0.0561 | 1 | 0.5 | |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0301 | 0.504 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.0561 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.504 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0561 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in Kunming mouse assessed as protection against subcutaneous pentylenetetrazol-induced clonic seizures at 300 mg/kg, ip measured after 0.5 hrs | ChEMBL. | 22727446 | |
Activity (ADMET) | Neurotoxicity in Kunming mouse at 300 mg/kg, ip after 4 hrs by rotorod test | ChEMBL. | 22727446 | |
Activity (functional) | Anticonvulsant activity in Kunming mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip measured after 4 hrs | ChEMBL. | 22727446 | |
Activity (functional) | Anticonvulsant activity in Kunming mouse assessed as protection against subcutaneous pentylenetetrazol-induced clonic seizures at 300 mg/kg, ip measured after 4 hrs | ChEMBL. | 22727446 | |
Activity (functional) | Anticonvulsant activity in Kunming mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip measured after 0.5 hr | ChEMBL. | 22727446 | |
Activity (ADMET) | Neurotoxicity in Kunming mouse at 100 mg/kg, ip after 0.5 hr by rotorod test | ChEMBL. | 22727446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.