Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | DNA gyrase subunit B | 0.0912 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0184 | 0.1736 | 0.4645 |
Echinococcus granulosus | microtubule associated protein 2 | 0.08 | 0.8726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.132 | 0.4287 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0912 | 1 | 1 |
Onchocerca volvulus | 0.0065 | 0.0381 | 0.1416 | |
Trypanosoma brucei | DNA topoisomerase ii | 0.0527 | 0.5628 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.08 | 0.8726 | 0.8912 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0213 | 0.2061 | 0.2362 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0527 | 0.5628 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0314 | 0.3207 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0213 | 0.2061 | 0.7901 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0014 | 0.0016 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.2605 | 0.7623 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0912 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0242 | 0.0234 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0148 | 0.132 | 0.1791 |
Onchocerca volvulus | 0.0261 | 0.2605 | 1 | |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0065 | 0.0381 | 0.1204 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0152 | 0.1372 | 0.4456 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0242 | 0.0278 |
Schistosoma mansoni | glutaminase | 0.0301 | 0.3062 | 0.3498 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0242 | 0.075 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0301 | 0.3062 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0912 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0213 | 0.2061 | 0.2094 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0065 | 0.0381 | 0.1204 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0322 | 0.3298 | 0.3033 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0242 | 0.075 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0065 | 0.0381 | 0.0436 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0213 | 0.2061 | 0.5759 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0213 | 0.2061 | 0.3647 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0065 | 0.0381 | 0.0367 |
Schistosoma mansoni | microtubule-associated protein tau | 0.08 | 0.8726 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0065 | 0.0381 | 0.0421 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0213 | 0.2061 | 0.205 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0893 | 0.979 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0213 | 0.2061 | 0.6717 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0242 | 0.0262 |
Mycobacterium ulcerans | glutaminase | 0.0301 | 0.3062 | 0.2787 |
Schistosoma mansoni | DNA topoisomerase II | 0.0213 | 0.2061 | 0.235 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0213 | 0.2061 | 0.6717 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0065 | 0.0381 | 0.0375 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0912 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0242 | 0.0262 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0148 | 0.132 | 0.1791 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0527 | 0.5628 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0148 | 0.132 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0148 | 0.132 | 0.1791 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0213 | 0.2061 | 0.6717 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0157 | 0.1427 | 0.3703 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0148 | 0.132 | 0.1791 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0213 | 0.2061 | 0.1747 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0598 | 0.6433 | 0.6292 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0065 | 0.0381 | 0.0436 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0213 | 0.2061 | 0.7901 |
Loa Loa (eye worm) | STAT protein | 0.0152 | 0.1372 | 0.4456 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.2245 | 0.7321 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0912 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0213 | 0.2061 | 0.6717 |
Brugia malayi | DNA topoisomerase III | 0.0065 | 0.0381 | 0.1204 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0242 | 0.0234 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.2245 | 0.7321 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0065 | 0.0381 | 0.0654 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0213 | 0.2061 | 0.7901 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3298 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0301 | 0.3062 | 0.9189 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0242 | 0.0262 |
Brugia malayi | GRF zinc finger family protein | 0.0065 | 0.0381 | 0.1204 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0213 | 0.2061 | 0.5759 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0065 | 0.0381 | 0.0375 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0157 | 0.1427 | 0.1088 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0065 | 0.0381 | 0.0421 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0065 | 0.0381 | 0.0654 |
Brugia malayi | glutaminase DH11.1 | 0.0301 | 0.3062 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0322 | 0.3298 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0527 | 0.5628 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0065 | 0.0381 | 0.1204 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0527 | 0.5628 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0242 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.132 | 0.4287 |
Loa Loa (eye worm) | glutaminase | 0.0301 | 0.3062 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.