Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.015 | 0.1213 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0303 | 0.6589 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0116 | 0 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0303 | 0.6589 | 0.6589 |
Treponema pallidum | flavodoxin | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0187 | 0.2507 | 0.2507 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0939 | 0.0939 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.6589 | 0.6589 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0303 | 0.6589 | 0.6589 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0303 | 0.6589 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0303 | 0.6589 | 0.6589 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0268 | 0.5376 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0399 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0268 | 0.5376 | 0.8159 |
Echinococcus granulosus | methionine synthase reductase | 0.0187 | 0.2507 | 0.2776 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0116 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0303 | 0.6589 | 0.6589 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0152 | 0.1294 | 0.0629 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0303 | 0.6589 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0187 | 0.2507 | 0.2507 |
Loa Loa (eye worm) | hypothetical protein | 0.0399 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0303 | 0.6589 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0303 | 0.6589 | 0.6589 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0939 | 0.0939 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.3116 | 0.3116 |
Leishmania major | p450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0116 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0303 | 0.6589 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0303 | 0.6589 | 0.6589 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0303 | 0.6589 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0268 | 0.5376 | 0.5376 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0303 | 0.6589 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0399 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0187 | 0.2507 | 0.2776 |
Giardia lamblia | Hypothetical protein | 0.0268 | 0.5376 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0187 | 0.2507 | 0.2776 |
Chlamydia trachomatis | sulfite reductase | 0.0187 | 0.2507 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.015 | 0.1213 | 0.0485 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0303 | 0.6589 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0268 | 0.5376 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.015 | 0.1213 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0303 | 0.6589 | 0.6589 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0303 | 0.6589 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.