Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0496 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0419 | 0.778 | 0.7488 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.1869 | 0.1869 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0246 | 0.279 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.044 | 0.8373 | 0.8159 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0496 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0306 | 0.4526 | 0.4526 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0306 | 0.4526 | 0.4526 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0306 | 0.4526 | 0.4526 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0419 | 0.778 | 0.7488 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0496 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0496 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0496 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0419 | 0.778 | 0.7488 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.019 | 0.1163 | 0.1163 |
Leishmania major | p450 reductase, putative | 0.0496 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.044 | 0.8373 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0496 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0496 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.019 | 0.1163 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0306 | 0.4526 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0246 | 0.279 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.044 | 0.8373 | 0.8159 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0496 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0496 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0496 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0306 | 0.4526 | 0.4526 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.044 | 0.8373 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.778 | 0.778 |
Giardia lamblia | Hypothetical protein | 0.044 | 0.8373 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0496 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0496 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0496 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0496 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.025 | 0.2899 | 0.2899 |
Entamoeba histolytica | type A flavoprotein, putative | 0.019 | 0.1163 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0496 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0419 | 0.778 | 0.7488 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0496 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.019 | 0.1163 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0496 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0246 | 0.279 | 0.279 |
Entamoeba histolytica | type A flavoprotein, putative | 0.019 | 0.1163 | 0.5 |
Treponema pallidum | flavodoxin | 0.019 | 0.1163 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0306 | 0.4526 | 0.3805 |
Entamoeba histolytica | type A flavoprotein, putative | 0.019 | 0.1163 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 23.3 % | Inhibition of nitrite level in LPS-induced mouse RAW264.7 cells at 5 uM by Griess assay relative to LPS treated control | ChEMBL. | 21183258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.