Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Peptide deformylase | Starlite/ChEMBL | References |
Staphylococcus aureus | Peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | adipor-like receptor | Peptide deformylase | 203 aa | 163 aa | 23.9 % |
Trichomonas vaginalis | abca6, putative | Peptide deformylase | 183 aa | 162 aa | 25.3 % |
Trypanosoma cruzi | hypothetical protein | Peptide deformylase | 183 aa | 155 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0558 | 1 | 0.5 |
Echinococcus multilocularis | cyclin g associated kinase | 0.0145 | 0.0353 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0558 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0558 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0558 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0145 | 0.0353 | 0.5 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.0145 | 0.0353 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0213 | 0.1931 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0213 | 0.1931 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0213 | 0.1931 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0213 | 0.1931 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0213 | 0.1931 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0213 | 0.1931 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.0353 | 0.5 |
Echinococcus granulosus | cyclin g associated kinase | 0.0145 | 0.0353 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0558 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0558 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0558 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0213 | 0.1931 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0558 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.38 nM | Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay | ChEMBL. | 22579486 |
IC50 (binding) | = 2.3 nM | Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay | ChEMBL. | 22579486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.