Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0424 | 0.0705 | 0.0604 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0246 | 0.0111 | 0.0111 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0267 | 0.0182 | 0.0079 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0246 | 0.0111 | 0.0003 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0424 | 0.0705 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0246 | 0.0111 | 0.0003 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.2189 | 0.6579 | 0.6541 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0246 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.067 | 0.1522 | 0.1522 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0424 | 0.0705 | 0.0604 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.1274 | 0.3532 | 0.4344 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0267 | 0.0182 | 0.0079 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0424 | 0.0705 | 0.0757 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.2971 | 0.9182 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0246 | 0.0111 | 0.0003 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0246 | 0.0111 | 0.0003 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0246 | 0.0111 | 0.0003 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.2189 | 0.6579 | 0.6541 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 0.1522 | 0.1522 |
Entamoeba histolytica | hypothetical protein | 0.0246 | 0.0111 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.067 | 0.1522 | 0.1795 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0246 | 0.0111 | 0.0004 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0246 | 0.0111 | 0.0111 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0245 | 0.0108 | 0.0108 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0246 | 0.0111 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0246 | 0.0111 | 0.0003 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0246 | 0.0111 | 0.0003 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.2367 | 0.7172 | 0.8963 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.3217 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0424 | 0.0705 | 0.0655 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0246 | 0.0111 | 0.0003 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.067 | 0.1522 | 0.1522 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0246 | 0.0111 | 0.0111 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0229 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.0705 | 0.0705 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0246 | 0.0111 | 0.0003 |
Echinococcus granulosus | tyrosine kinase | 0.0246 | 0.0111 | 0.0003 |
Echinococcus granulosus | glutamate receptor 2 | 0.0246 | 0.0111 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0246 | 0.0111 | 0.0004 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0246 | 0.0111 | 0.0004 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.2613 | 0.799 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.3217 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.1028 | 0.2714 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0246 | 0.0111 | 0.0003 |
Leishmania major | extracellular receptor, putative | 0.0246 | 0.0111 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | glutamate receptor | 0.2613 | 0.799 | 0.799 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0246 | 0.0111 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.2189 | 0.6579 | 0.713 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0229 | 0.0054 | 0.5 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0246 | 0.0111 | 0.0004 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0424 | 0.0705 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1274 | 0.3532 | 0.3772 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0111 | 0.0111 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0246 | 0.0111 | 0.0003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 24 % | Displacement of [125I]-CXCL12 from CXCR4 expressed in human Jurkat cells at 10 uM relative to T140 | ChEMBL. | 22579418 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.