Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | smoothened, frizzled class receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | smoothened | Get druggable targets OG5_134998 | All targets in OG5_134998 |
Echinococcus granulosus | smoothened | Get druggable targets OG5_134998 | All targets in OG5_134998 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134998 | All targets in OG5_134998 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0175 | 0.0977 | 0.1791 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.108 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0624 | 0.5455 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0252 | 0.1747 | 0.1747 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0252 | 0.1747 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0175 | 0.0977 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0977 | 0.3021 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.108 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0252 | 0.1747 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0252 | 0.1747 | 0.5264 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0175 | 0.0977 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0977 | 0.3021 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.108 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0252 | 0.1747 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0252 | 0.1747 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0252 | 0.1747 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.108 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0624 | 0.5455 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.108 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.108 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0624 | 0.5455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.3234 | 1 |
Echinococcus granulosus | smoothened | 0.041 | 0.3319 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0372 | 0.2938 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0252 | 0.1747 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0252 | 0.1747 | 0.5402 |
Giardia lamblia | DNA topoisomerase II | 0.0219 | 0.1409 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0708 | 0.6292 | 0.6292 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0252 | 0.1747 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0252 | 0.1747 | 1 |
Echinococcus multilocularis | smoothened | 0.041 | 0.3319 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0175 | 0.0977 | 0.1791 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0624 | 0.5455 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0175 | 0.0977 | 0.1791 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0252 | 0.1747 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0252 | 0.1747 | 0.1747 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0252 | 0.1747 | 0.3202 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0624 | 0.5455 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0252 | 0.1747 | 0.5264 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.19 uM | Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assay | ChEMBL. | 22268551 |
Inhibition (functional) | = 69 % | Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells at 0.3 uM by luciferase reporter gene assay | ChEMBL. | 22268551 |
Inhibition (functional) | = 89 % | Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells at 3 uM by luciferase reporter gene assay | ChEMBL. | 22268551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.